CD80 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD274	CD28	ENSPTRP00000035504	ENSPTRP00000021943	CD274 isoform 2.	CD28 isoform 3.	0.448
CD274	CD4	ENSPTRP00000035504	ENSPTRP00000054833	CD274 isoform 2.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.722
CD274	CD40	ENSPTRP00000035504	ENSPTRP00000068307	CD274 isoform 2.	CD40 molecule, TNF receptor superfamily member 5.	0.535
CD274	CD80	ENSPTRP00000035504	ENSPTRP00000026304	CD274 isoform 2.	CD80 isoform 1.	0.966
CD274	CD83	ENSPTRP00000035504	ENSPTRP00000030293	CD274 isoform 2.	CD83 isoform 2.	0.405
CD274	CD86	ENSPTRP00000035504	ENSPTRP00000026356	CD274 isoform 2.	CD86 isoform 3.	0.499
CD274	CTLA4	ENSPTRP00000035504	ENSPTRP00000080210	CD274 isoform 2.	Cytotoxic T-lymphocyte associated protein 4.	0.720
CD274	IFNG	ENSPTRP00000035504	ENSPTRP00000008822	CD274 isoform 2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.676
CD274	IL10	ENSPTRP00000035504	ENSPTRP00000003208	CD274 isoform 2.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.587
CD28	CD274	ENSPTRP00000021943	ENSPTRP00000035504	CD28 isoform 3.	CD274 isoform 2.	0.448
CD28	CD4	ENSPTRP00000021943	ENSPTRP00000054833	CD28 isoform 3.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.945
CD28	CD40	ENSPTRP00000021943	ENSPTRP00000068307	CD28 isoform 3.	CD40 molecule, TNF receptor superfamily member 5.	0.519
CD28	CD80	ENSPTRP00000021943	ENSPTRP00000026304	CD28 isoform 3.	CD80 isoform 1.	0.999
CD28	CD86	ENSPTRP00000021943	ENSPTRP00000026356	CD28 isoform 3.	CD86 isoform 3.	0.998
CD28	CTLA4	ENSPTRP00000021943	ENSPTRP00000080210	CD28 isoform 3.	Cytotoxic T-lymphocyte associated protein 4.	0.768
CD28	IFNG	ENSPTRP00000021943	ENSPTRP00000008822	CD28 isoform 3.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity).	0.818
CD28	IL10	ENSPTRP00000021943	ENSPTRP00000003208	CD28 isoform 3.	Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...]	0.689
CD4	CD274	ENSPTRP00000054833	ENSPTRP00000035504	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	CD274 isoform 2.	0.722
CD4	CD28	ENSPTRP00000054833	ENSPTRP00000021943	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	CD28 isoform 3.	0.945
CD4	CD40	ENSPTRP00000054833	ENSPTRP00000068307	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	CD40 molecule, TNF receptor superfamily member 5.	0.933