| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACE | CMA1 | ENSPTRP00000038991 | ENSPTRP00000010563 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | CMA1 isoform 1; Belongs to the peptidase S1 family. | 0.589 |
| ACE | CPA3 | ENSPTRP00000038991 | ENSPTRP00000026701 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | CPA3 isoform 1. | 0.910 |
| ACE | MME | ENSPTRP00000038991 | ENSPTRP00000090405 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Membrane metallo-endopeptidase. | 0.969 |
| ACE | REN | ENSPTRP00000038991 | ENSPTRP00000051292 | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.991 |
| CMA1 | ACE | ENSPTRP00000010563 | ENSPTRP00000038991 | CMA1 isoform 1; Belongs to the peptidase S1 family. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.589 |
| CMA1 | CPA3 | ENSPTRP00000010563 | ENSPTRP00000026701 | CMA1 isoform 1; Belongs to the peptidase S1 family. | CPA3 isoform 1. | 0.938 |
| CMA1 | FCER1A | ENSPTRP00000010563 | ENSPTRP00000002567 | CMA1 isoform 1; Belongs to the peptidase S1 family. | FCER1A isoform 1. | 0.605 |
| CMA1 | MS4A2 | ENSPTRP00000010563 | ENSPTRP00000006387 | CMA1 isoform 1; Belongs to the peptidase S1 family. | Membrane spanning 4-domains A2. | 0.607 |
| CMA1 | REN | ENSPTRP00000010563 | ENSPTRP00000051292 | CMA1 isoform 1; Belongs to the peptidase S1 family. | Renin; Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. | 0.945 |
| CPA1 | CPA2 | ENSPTRP00000033736 | ENSPTRP00000033732 | CPA1 isoform 2. | Carboxypeptidase A2. | 0.984 |
| CPA1 | CPA3 | ENSPTRP00000033736 | ENSPTRP00000026701 | CPA1 isoform 2. | CPA3 isoform 1. | 0.918 |
| CPA2 | CPA1 | ENSPTRP00000033732 | ENSPTRP00000033736 | Carboxypeptidase A2. | CPA1 isoform 2. | 0.984 |
| CPA2 | CPA3 | ENSPTRP00000033732 | ENSPTRP00000026701 | Carboxypeptidase A2. | CPA3 isoform 1. | 0.925 |
| CPA3 | ACE | ENSPTRP00000026701 | ENSPTRP00000038991 | CPA3 isoform 1. | Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family. | 0.910 |
| CPA3 | CMA1 | ENSPTRP00000026701 | ENSPTRP00000010563 | CPA3 isoform 1. | CMA1 isoform 1; Belongs to the peptidase S1 family. | 0.938 |
| CPA3 | CPA1 | ENSPTRP00000026701 | ENSPTRP00000033736 | CPA3 isoform 1. | CPA1 isoform 2. | 0.918 |
| CPA3 | CPA2 | ENSPTRP00000026701 | ENSPTRP00000033732 | CPA3 isoform 1. | Carboxypeptidase A2. | 0.925 |
| CPA3 | FCER1A | ENSPTRP00000026701 | ENSPTRP00000002567 | CPA3 isoform 1. | FCER1A isoform 1. | 0.897 |
| CPA3 | HDC | ENSPTRP00000026701 | ENSPTRP00000012071 | CPA3 isoform 1. | Histidine decarboxylase. | 0.879 |
| CPA3 | MME | ENSPTRP00000026701 | ENSPTRP00000090405 | CPA3 isoform 1. | Membrane metallo-endopeptidase. | 0.904 |
