STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KNG1KNG1 isoform 2. (644 aa)    
Predicted Functional Partners:
BDKRB1
Bradykinin receptor B1.
    
 0.999
BDKRB2
B2 bradykinin receptor isoform X1.
    
 0.999
KLKB1
KLKB1 isoform 2; Belongs to the peptidase S1 family.
   
 0.997
ACE
Angiotensin-converting enzyme, soluble form; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI- anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety (By similarity); Belongs to the peptidase M2 family.
    
 0.975
EDNRB
Endothelin receptor type B; Belongs to the G-protein coupled receptor 1 family.
    
 0.954
EDNRA
Endothelin receptor type A; Belongs to the G-protein coupled receptor 1 family.
    
 0.954
OPRD1
Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family.
   
 0.949
C1QBP
Complement component 1, q subcomponent binding protein.
    
 0.945
F12
Coagulation factor XII.
   
 0.941
F11
Coagulation factor XI; Belongs to the peptidase S1 family.
   
 0.926
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.