| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CD81 | CLDN1 | ENSPTRP00000074537 | ENSPTRP00000027073 | CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.814 |
| CD81 | EPHA2 | ENSPTRP00000074537 | ENSPTRP00000000400 | CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] | EPH receptor A2. | 0.786 |
| CD81 | NPC1L1 | ENSPTRP00000074537 | ENSPTRP00000048020 | CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] | NPC1 like intracellular cholesterol transporter 1. | 0.819 |
| CD81 | SEC14L2 | ENSPTRP00000074537 | ENSPTRP00000056683 | CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] | SEC14-like protein 2 isoform X3. | 0.648 |
| CLDN1 | CD81 | ENSPTRP00000027073 | ENSPTRP00000074537 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | CD81 antigen; Structural component of specialized membrane microdomains known as tetraspanin-enriched microdomains (TERMs), which act as platforms for receptor clustering and signaling. Essential for trafficking and compartmentalization of CD19 receptor on the surface of activated B cells. Upon initial encounter with microbial pathogens, enables the assembly of CD19-CR2/CD21 and B cell receptor (BCR) complexes at signaling TERMs, lowering the threshold dose of antigen required to trigger B cell clonal expansion and antibody production. In T cells, facilitates the localization of CD247/ [...] | 0.814 |
| CLDN1 | CLDN12 | ENSPTRP00000027073 | ENSPTRP00000076827 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | CLDN12 isoform 2. | 0.867 |
| CLDN1 | CLDN16 | ENSPTRP00000027073 | ENSPTRP00000027074 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.805 |
| CLDN1 | CLDN23 | ENSPTRP00000027073 | ENSPTRP00000060615 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.773 |
| CLDN1 | EPHA2 | ENSPTRP00000027073 | ENSPTRP00000000400 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | EPH receptor A2. | 0.824 |
| CLDN1 | NPC1L1 | ENSPTRP00000027073 | ENSPTRP00000048020 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | NPC1 like intracellular cholesterol transporter 1. | 0.891 |
| CLDN1 | OCLN | ENSPTRP00000027073 | ENSPTRP00000054719 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. | 0.782 |
| CLDN1 | SEC14L2 | ENSPTRP00000027073 | ENSPTRP00000056683 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | SEC14-like protein 2 isoform X3. | 0.769 |
| CLDN1 | TJP1 | ENSPTRP00000027073 | ENSPTRP00000011701 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein 1; Belongs to the MAGUK family. | 0.961 |
| CLDN1 | TJP3 | ENSPTRP00000027073 | ENSPTRP00000017461 | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | Tight junction protein 3; Belongs to the MAGUK family. | 0.919 |
| CLDN12 | CLDN1 | ENSPTRP00000076827 | ENSPTRP00000027073 | CLDN12 isoform 2. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.867 |
| CLDN12 | CLDN16 | ENSPTRP00000076827 | ENSPTRP00000027074 | CLDN12 isoform 2. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.818 |
| CLDN12 | CLDN23 | ENSPTRP00000076827 | ENSPTRP00000060615 | CLDN12 isoform 2. | Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. | 0.732 |
| CLDN12 | OCLN | ENSPTRP00000076827 | ENSPTRP00000054719 | CLDN12 isoform 2. | Occludin; May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the ELL/occludin family. | 0.650 |
| CLDN12 | TJP1 | ENSPTRP00000076827 | ENSPTRP00000011701 | CLDN12 isoform 2. | Tight junction protein 1; Belongs to the MAGUK family. | 0.790 |
| CLDN12 | TJP3 | ENSPTRP00000076827 | ENSPTRP00000017461 | CLDN12 isoform 2. | Tight junction protein 3; Belongs to the MAGUK family. | 0.750 |
