IL1RAP protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IL1A	IL1B	ENSPTRP00000021189	ENSPTRP00000021191	Interleukin-1; Belongs to the IL-1 family.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.999
IL1A	IL1F10	ENSPTRP00000021189	ENSPTRP00000021198	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.512
IL1A	IL1R1	ENSPTRP00000021189	ENSPTRP00000075043	Interleukin-1; Belongs to the IL-1 family.	Interleukin 1 receptor, type I.	0.997
IL1A	IL1RAP	ENSPTRP00000021189	ENSPTRP00000083273	Interleukin-1; Belongs to the IL-1 family.	Interleukin 1 receptor accessory protein.	0.974
IL1A	IL1RL2	ENSPTRP00000021189	ENSPTRP00000021069	Interleukin-1; Belongs to the IL-1 family.	IL1RL2 isoform 1.	0.911
IL1A	IL33	ENSPTRP00000021189	ENSPTRP00000035514	Interleukin-1; Belongs to the IL-1 family.	IL33 isoform 1.	0.702
IL1A	IL36RN	ENSPTRP00000021189	ENSPTRP00000075102	Interleukin-1; Belongs to the IL-1 family.	Interleukin-1.	0.584
IL1A	LOC459462	ENSPTRP00000021189	ENSPTRP00000066262	Interleukin-1; Belongs to the IL-1 family.	Uncharacterized protein.	0.744
IL1A	MYD88	ENSPTRP00000021189	ENSPTRP00000061524	Interleukin-1; Belongs to the IL-1 family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.765
IL1B	IL1A	ENSPTRP00000021191	ENSPTRP00000021189	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1; Belongs to the IL-1 family.	0.999
IL1B	IL1F10	ENSPTRP00000021191	ENSPTRP00000021198	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.587
IL1B	IL1R1	ENSPTRP00000021191	ENSPTRP00000075043	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin 1 receptor, type I.	0.997
IL1B	IL1RAP	ENSPTRP00000021191	ENSPTRP00000083273	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin 1 receptor accessory protein.	0.994
IL1B	IL1RL2	ENSPTRP00000021191	ENSPTRP00000021069	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	IL1RL2 isoform 1.	0.895
IL1B	IL33	ENSPTRP00000021191	ENSPTRP00000035514	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	IL33 isoform 1.	0.675
IL1B	IL36RN	ENSPTRP00000021191	ENSPTRP00000075102	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Interleukin-1.	0.685
IL1B	LOC459462	ENSPTRP00000021191	ENSPTRP00000066262	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Uncharacterized protein.	0.725
IL1B	MYD88	ENSPTRP00000021191	ENSPTRP00000061524	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.842
IL1F10	IL1A	ENSPTRP00000021198	ENSPTRP00000021189	Interleukin-1.	Interleukin-1; Belongs to the IL-1 family.	0.512
IL1F10	IL1B	ENSPTRP00000021198	ENSPTRP00000021191	Interleukin-1.	Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.	0.587