STAP1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABCG5	LDLRAP1	ENSPTRP00000020391	ENSPTRP00000000643	ATP binding cassette subfamily G member 5.	Low density lipoprotein receptor adaptor protein 1.	0.557
ABCG5	PCSK9	ENSPTRP00000020391	ENSPTRP00000001355	ATP binding cassette subfamily G member 5.	Proprotein convertase subtilisin/kexin type 9; Crucial player in the regulation of plasma cholesterol homeostasis. Binds to low-density lipid receptor family members: low density lipoprotein receptor (LDLR), very low density lipoprotein receptor (VLDLR), apolipoprotein E receptor (LRP1/APOER) and apolipoprotein receptor 2 (LRP8/APOER2), and promotes their degradation in intracellular acidic compartments. Acts via a non-proteolytic mechanism to enhance the degradation of the hepatic LDLR through a clathrin LDLRAP1/ARH-mediated pathway. May prevent the recycling of LDLR from endosomes to [...]	0.572
ABCG5	STAP1	ENSPTRP00000020391	ENSPTRP00000027687	ATP binding cassette subfamily G member 5.	Signal transducing adaptor family member 1.	0.665
BMX	STAP1	ENSPTRP00000092350	ENSPTRP00000027687	Tyrosine-protein kinase.	Signal transducing adaptor family member 1.	0.536
CAPZA1	CAPZA2	ENSPTRP00000057790	ENSPTRP00000047674	Capping actin protein of muscle Z-line subunit alpha 1.	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).	0.975
CAPZA1	CAPZA3	ENSPTRP00000057790	ENSPTRP00000008098	Capping actin protein of muscle Z-line subunit alpha 1.	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.818
CAPZA1	CAPZB	ENSPTRP00000057790	ENSPTRP00000072044	Capping actin protein of muscle Z-line subunit alpha 1.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.986
CAPZA1	CD2AP	ENSPTRP00000057790	ENSPTRP00000084816	Capping actin protein of muscle Z-line subunit alpha 1.	CD2-associated protein.	0.810
CAPZA1	SH3KBP1	ENSPTRP00000057790	ENSPTRP00000082485	Capping actin protein of muscle Z-line subunit alpha 1.	SH3KBP1 isoform 2.	0.813
CAPZA1	STAP1	ENSPTRP00000057790	ENSPTRP00000027687	Capping actin protein of muscle Z-line subunit alpha 1.	Signal transducing adaptor family member 1.	0.447
CAPZA2	CAPZA1	ENSPTRP00000047674	ENSPTRP00000057790	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).	Capping actin protein of muscle Z-line subunit alpha 1.	0.975
CAPZA2	CAPZA3	ENSPTRP00000047674	ENSPTRP00000008098	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.920
CAPZA2	CAPZB	ENSPTRP00000047674	ENSPTRP00000072044	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.999
CAPZA2	CD2AP	ENSPTRP00000047674	ENSPTRP00000084816	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).	CD2-associated protein.	0.830
CAPZA2	SH3KBP1	ENSPTRP00000047674	ENSPTRP00000082485	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).	SH3KBP1 isoform 2.	0.835
CAPZA2	STAP1	ENSPTRP00000047674	ENSPTRP00000027687	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).	Signal transducing adaptor family member 1.	0.690
CAPZA3	CAPZA1	ENSPTRP00000008098	ENSPTRP00000057790	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	Capping actin protein of muscle Z-line subunit alpha 1.	0.818
CAPZA3	CAPZA2	ENSPTRP00000008098	ENSPTRP00000047674	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).	0.920
CAPZA3	CAPZB	ENSPTRP00000008098	ENSPTRP00000072044	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	F-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	0.997
CAPZA3	CD2AP	ENSPTRP00000008098	ENSPTRP00000084816	F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.	CD2-associated protein.	0.668