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TLR2 protein (Pan troglodytes) - STRING interaction network
"TLR2" - Toll-like receptor 2 in Pan troglodytes
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)    
Predicted Functional Partners:
CD14
Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2-TLR6 heterodimer in response to diacylated lipopeptides and for TLR2-TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (374 aa)
     
  0.970
TLR1
Pan troglodytes toll-like receptor 1 (TLR1), mRNA (786 aa)
     
0.964
TIRAP
Pan troglodytes toll-interleukin 1 receptor (TIR) domain containing adaptor protein (TIRAP), mRNA (221 aa)
       
  0.945
TLR6
Pan troglodytes toll-like receptor 6 (TLR6), mRNA (796 aa)
     
0.944
MYD88
Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] (296 aa)
     
0.921
TICAM1
Uncharacterized protein; TIR domain-containing adapter molecule 1 (711 aa)
     
 
  0.909
IL6
Interleukin 6 (Interferon, beta 2); Uncharacterized protein (212 aa)
     
   
  0.907
HSPA1A
Uncharacterized protein; Belongs to the heat shock protein 70 family (641 aa)
       
  0.889
IL10
Interleukin-10; Inhibits the synthesis of a number of cytokines, including IFN-gamma, IL-2, IL-3, TNF and GM-CSF produced by activated macrophages and by helper T-cells (178 aa)
     
 
  0.883
RELA
Pan troglodytes v-rel reticuloendotheliosis viral oncogene homolog A (avian) (RELA), mRNA (551 aa)
     
  0.880
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, Pan troglodytes, chimpanzee
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