TDO2 protein (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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proteins of unknown 3D structure

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Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFMID	DDC	ENSPTRP00000016506	ENSPTRP00000091008	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Dopa decarboxylase.	0.909
AFMID	IDO1	ENSPTRP00000016506	ENSPTRP00000034569	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	IDO1 isoform 2.	0.954
AFMID	IDO2	ENSPTRP00000016506	ENSPTRP00000034571	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	IDO2 isoform 4.	0.967
AFMID	KYNU	ENSPTRP00000016506	ENSPTRP00000067734	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.985
AFMID	TDO2	ENSPTRP00000016506	ENSPTRP00000028403	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.981
ASMTL	DDC	ENSPTRP00000092412	ENSPTRP00000091008	ASMTL isoform 3.	Dopa decarboxylase.	0.407
ASMTL	TDO2	ENSPTRP00000092412	ENSPTRP00000028403	ASMTL isoform 3.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.822
DDC	AFMID	ENSPTRP00000091008	ENSPTRP00000016506	Dopa decarboxylase.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.909
DDC	ASMTL	ENSPTRP00000091008	ENSPTRP00000092412	Dopa decarboxylase.	ASMTL isoform 3.	0.407
DDC	IDO1	ENSPTRP00000091008	ENSPTRP00000034569	Dopa decarboxylase.	IDO1 isoform 2.	0.963
DDC	IDO2	ENSPTRP00000091008	ENSPTRP00000034571	Dopa decarboxylase.	IDO2 isoform 4.	0.955
DDC	IL4I1	ENSPTRP00000091008	ENSPTRP00000055736	Dopa decarboxylase.	Amine oxidase.	0.904
DDC	KYNU	ENSPTRP00000091008	ENSPTRP00000067734	Dopa decarboxylase.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.564
DDC	TAT	ENSPTRP00000091008	ENSPTRP00000014220	Dopa decarboxylase.	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate.	0.929
DDC	TDO2	ENSPTRP00000091008	ENSPTRP00000028403	Dopa decarboxylase.	Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.	0.962
DDC	TPH1	ENSPTRP00000091008	ENSPTRP00000078167	Dopa decarboxylase.	Tryptophan hydroxylase 1.	0.970
DDC	TPH2	ENSPTRP00000091008	ENSPTRP00000088217	Dopa decarboxylase.	Tryptophan hydroxylase 2.	0.967
IDO1	AFMID	ENSPTRP00000034569	ENSPTRP00000016506	IDO1 isoform 2.	Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.	0.954
IDO1	DDC	ENSPTRP00000034569	ENSPTRP00000091008	IDO1 isoform 2.	Dopa decarboxylase.	0.963
IDO1	IDO2	ENSPTRP00000034569	ENSPTRP00000034571	IDO1 isoform 2.	IDO2 isoform 4.	0.928