| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AADAT | AFMID | ENSPTRP00000028475 | ENSPTRP00000016506 | Aminoadipate aminotransferase. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.937 |
| AADAT | ALDH7A1 | ENSPTRP00000028475 | ENSPTRP00000064794 | Aminoadipate aminotransferase. | ALDH7A1 isoform 8; Belongs to the aldehyde dehydrogenase family. | 0.924 |
| AADAT | DHTKD1 | ENSPTRP00000028475 | ENSPTRP00000063557 | Aminoadipate aminotransferase. | Dehydrogenase E1 and transketolase domain containing 1. | 0.941 |
| AADAT | DRC7 | ENSPTRP00000028475 | ENSPTRP00000075558 | Aminoadipate aminotransferase. | Dynein regulatory complex subunit 7; Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility; Belongs to the DRC7 family. | 0.812 |
| AADAT | KMO | ENSPTRP00000028475 | ENSPTRP00000072192 | Aminoadipate aminotransferase. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.959 |
| AADAT | KYAT1 | ENSPTRP00000028475 | ENSPTRP00000063694 | Aminoadipate aminotransferase. | Kynurenine aminotransferase 1. | 0.961 |
| AADAT | KYAT3 | ENSPTRP00000028475 | ENSPTRP00000001612 | Aminoadipate aminotransferase. | Cysteine conjugate-beta lyase 2. | 0.945 |
| AADAT | KYNU | ENSPTRP00000028475 | ENSPTRP00000067734 | Aminoadipate aminotransferase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.953 |
| AADAT | RALYL | ENSPTRP00000028475 | ENSPTRP00000075083 | Aminoadipate aminotransferase. | RALYL isoform 1. | 0.831 |
| AADAT | SHE | ENSPTRP00000028475 | ENSPTRP00000002336 | Aminoadipate aminotransferase. | Src homology 2 domain containing E. | 0.874 |
| AFMID | AADAT | ENSPTRP00000016506 | ENSPTRP00000028475 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Aminoadipate aminotransferase. | 0.937 |
| AFMID | KMO | ENSPTRP00000016506 | ENSPTRP00000072192 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.970 |
| AFMID | KYAT1 | ENSPTRP00000016506 | ENSPTRP00000063694 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynurenine aminotransferase 1. | 0.938 |
| AFMID | KYAT3 | ENSPTRP00000016506 | ENSPTRP00000001612 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Cysteine conjugate-beta lyase 2. | 0.934 |
| AFMID | KYNU | ENSPTRP00000016506 | ENSPTRP00000067734 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.985 |
| ALDH7A1 | AADAT | ENSPTRP00000064794 | ENSPTRP00000028475 | ALDH7A1 isoform 8; Belongs to the aldehyde dehydrogenase family. | Aminoadipate aminotransferase. | 0.924 |
| ALDH7A1 | DHTKD1 | ENSPTRP00000064794 | ENSPTRP00000063557 | ALDH7A1 isoform 8; Belongs to the aldehyde dehydrogenase family. | Dehydrogenase E1 and transketolase domain containing 1. | 0.413 |
| DHTKD1 | AADAT | ENSPTRP00000063557 | ENSPTRP00000028475 | Dehydrogenase E1 and transketolase domain containing 1. | Aminoadipate aminotransferase. | 0.941 |
| DHTKD1 | ALDH7A1 | ENSPTRP00000063557 | ENSPTRP00000064794 | Dehydrogenase E1 and transketolase domain containing 1. | ALDH7A1 isoform 8; Belongs to the aldehyde dehydrogenase family. | 0.413 |
| DHTKD1 | KMO | ENSPTRP00000063557 | ENSPTRP00000072192 | Dehydrogenase E1 and transketolase domain containing 1. | Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. | 0.559 |
