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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IRX1Iroquois homeobox 1. (480 aa)    
Predicted Functional Partners:
CLK4
CDC-like kinase 4; Belongs to the protein kinase superfamily.
   
  
 0.788
KCND2
Potassium voltage-gated channel, Shal-related subfamily, member 2; Belongs to the potassium channel family.
      
 0.662
TSHZ1
TSHZ1 isoform 2.
   
 0.611
SMYD1
SET and MYND domain containing 1.
    
 0.600
HEY1
Hes related family bHLH transcription factor with YRPW motif 1.
      
 0.586
IRX2
Iroquois homeobox 2.
   
  
0.571
IRX6
Iroquois homeobox 6.
   
 
0.554
DLX2
Distal-less homeobox 2.
   
 
 0.552
HAND2
Heart and neural crest derivatives expressed 2.
      
 0.545
ANHX
Anomalous homeobox.
   
  
 0.514
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.