| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMT | DHFR | ENSPTRP00000025761 | ENSPTRP00000029175 | Aminomethyltransferase, mitochondrial isoform X2. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.955 |
| AMT | DHFR2 | ENSPTRP00000025761 | ENSPTRP00000091206 | Aminomethyltransferase, mitochondrial isoform X2. | DHFR2 isoform 2. | 0.955 |
| AMT | DMGDH | ENSPTRP00000025761 | ENSPTRP00000029147 | Aminomethyltransferase, mitochondrial isoform X2. | Dimethylglycine dehydrogenase. | 0.909 |
| AMT | FPGS | ENSPTRP00000025761 | ENSPTRP00000085569 | Aminomethyltransferase, mitochondrial isoform X2. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.602 |
| AMT | MTHFD1 | ENSPTRP00000025761 | ENSPTRP00000010916 | Aminomethyltransferase, mitochondrial isoform X2. | MTHFD1 isoform 1. | 0.946 |
| AMT | MTHFD1L | ENSPTRP00000025761 | ENSPTRP00000031922 | Aminomethyltransferase, mitochondrial isoform X2. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. | 0.946 |
| AMT | SARDH | ENSPTRP00000025761 | ENSPTRP00000036833 | Aminomethyltransferase, mitochondrial isoform X2. | Sarcosine dehydrogenase. | 0.909 |
| AMT | SHMT1 | ENSPTRP00000025761 | ENSPTRP00000076664 | Aminomethyltransferase, mitochondrial isoform X2. | Serine hydroxymethyltransferase 1. | 0.978 |
| AMT | SHMT2 | ENSPTRP00000025761 | ENSPTRP00000063004 | Aminomethyltransferase, mitochondrial isoform X2. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.978 |
| AMT | TYMS | ENSPTRP00000025761 | ENSPTRP00000016716 | Aminomethyltransferase, mitochondrial isoform X2. | Thymidylate synthetase. | 0.963 |
| DHFR | AMT | ENSPTRP00000029175 | ENSPTRP00000025761 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Aminomethyltransferase, mitochondrial isoform X2. | 0.955 |
| DHFR | DHFR2 | ENSPTRP00000029175 | ENSPTRP00000091206 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | DHFR2 isoform 2. | 0.972 |
| DHFR | DMGDH | ENSPTRP00000029175 | ENSPTRP00000029147 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Dimethylglycine dehydrogenase. | 0.971 |
| DHFR | FPGS | ENSPTRP00000029175 | ENSPTRP00000085569 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.979 |
| DHFR | MTHFD1 | ENSPTRP00000029175 | ENSPTRP00000010916 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | MTHFD1 isoform 1. | 0.963 |
| DHFR | MTHFD1L | ENSPTRP00000029175 | ENSPTRP00000031922 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. | 0.956 |
| DHFR | SARDH | ENSPTRP00000029175 | ENSPTRP00000036833 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Sarcosine dehydrogenase. | 0.977 |
| DHFR | SHMT1 | ENSPTRP00000029175 | ENSPTRP00000076664 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase 1. | 0.976 |
| DHFR | SHMT2 | ENSPTRP00000029175 | ENSPTRP00000063004 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.978 |
| DHFR | TYMS | ENSPTRP00000029175 | ENSPTRP00000016716 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate synthetase. | 0.999 |
