STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KLHL3Kelch like family member 3. (608 aa)    
Predicted Functional Partners:
CUL3
CUL3 isoform 2; Belongs to the cullin family.
    
 0.997
WNK4
WNK lysine deficient protein kinase 4.
    
 
 0.939
WNK1
WNK1 isoform 4.
    
 
 0.903
WNK3
WNK3 isoform 5.
    
 
 0.827
KLHL12
Kelch like family member 12.
  
 
 
0.802
RBX1
Ring-box 1, E3 ubiquitin protein ligase.
    
 0.783
KLHL2
Kelch like family member 2.
  
 
0.751
KEAP1
Kelch-like ECH-associated protein 1.
  
 
 
0.747
ACKR1
Atypical chemokine receptor 1; Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine- binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for [...]
      
 0.681
KBTBD8
Kelch repeat and BTB domain containing 8.
    
0.597
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.