STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
RGS14Regulator of G protein signaling 14. (566 aa)    
Predicted Functional Partners:
GNAI1
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.
   
 0.978
RAP1A
RAP1A, member of RAS oncogene family.
    
 0.940
ITGB2
Integrin beta.
   
 0.925
RAP1B
Ras-related protein Rap-1b; GTP-binding protein that possesses intrinsic GTPase activity. Contributes to the polarizing activity of KRIT1 and CDH5 in the establishment and maintenance of correct endothelial cell polarity and vascular lumen. Required for the localization of phosphorylated PRKCZ, PARD3 and TIAM1 to the cell junction. Plays a role in the establishment of basal endothelial barrier function (By similarity); Belongs to the small GTPase superfamily. Ras family.
    
 0.906
ITGAM
Integrin subunit alpha M; Belongs to the integrin alpha chain family.
   
 
  0.903
ITGAL
ITGAL isoform 4.
   
 
  0.903
ITGB1
Integrin beta; Belongs to the integrin beta chain family.
   
 0.903
GNAI3
Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.
   
 0.871
GNAO1
G protein subunit alpha o1.
   
 0.753
GFRA2
GDNF family receptor alpha-2; Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor.
   
  
 0.676
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.