STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
GTF2H4General transcription factor IIH subunit 4; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (462 aa)    
Predicted Functional Partners:
GTF2H2C
General transcription factor IIH subunit.
   
 0.999
GTF2H3
General transcription factor IIH, polypeptide 3, 34kDa.
   
 0.999
GTF2H5
General transcription factor IIH, polypeptide 5.
    
 0.999
ERCC3
ERCC excision repair 3, TFIIH core complex helicase subunit.
  
 0.999
ERCC2
ERCC excision repair 2, TFIIH core complex helicase subunit.
    
 0.997
CCNH
CCNH isoform 1; Belongs to the cyclin family.
    
 0.994
MNAT1
CDK-activating kinase assembly factor MAT1; Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex.
    
 0.994
CDK7
Cyclin-dependent kinase 7; Belongs to the protein kinase superfamily.
    
 0.992
GTF2H1
General transcription factor IIH, polypeptide 1, 62kDa.
    
 0.991
CK820_G0005641
GTF2H1 isoform 5.
    
 0.991
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.