MSH5 protein (Pan troglodytes) - STRING interaction network

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Score

MSH5

DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (839 aa)

Predicted Functional Partners:

MSH4

0.996

MLH3

0.932

MLH1

0.910

PMS1

0.904

CK820_G0052740

0.894

CK820_G0047513

0.894

PMS2

0.894

SYCE2

0.761

ATAT1

0.744

ATM

0.737

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATAT1	MSH5	ENSPTRP00000030594	ENSPTRP00000030697	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.744
ATAT1	SYCE2	ENSPTRP00000030594	ENSPTRP00000018008	Alpha-tubulin N-acetyltransferase 1; Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dyn [...]	Synaptonemal complex central element protein 2.	0.739
ATM	CK820_G0047513	ENSPTRP00000054216	ENSPTRP00000080387	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Uncharacterized protein.	0.721
ATM	CK820_G0052740	ENSPTRP00000054216	ENSPTRP00000032326	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PMS2 isoform 6.	0.721
ATM	MLH1	ENSPTRP00000054216	ENSPTRP00000025426	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MutL homolog 1, colon cancer, nonpolyposis type 2.	0.945
ATM	MLH3	ENSPTRP00000054216	ENSPTRP00000076885	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MLH3 isoform 1.	0.753
ATM	MSH4	ENSPTRP00000054216	ENSPTRP00000084312	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	MSH4 isoform 1.	0.656
ATM	MSH5	ENSPTRP00000054216	ENSPTRP00000030697	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.737
ATM	PMS1	ENSPTRP00000054216	ENSPTRP00000066616	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PMS1 homolog 1, mismatch repair system component.	0.743
ATM	PMS2	ENSPTRP00000054216	ENSPTRP00000090549	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	PMS1 homolog 2, mismatch repair system component.	0.721
CK820_G0047513	ATM	ENSPTRP00000080387	ENSPTRP00000054216	Uncharacterized protein.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.721
CK820_G0047513	CK820_G0052740	ENSPTRP00000080387	ENSPTRP00000032326	Uncharacterized protein.	PMS2 isoform 6.	0.544
CK820_G0047513	MLH1	ENSPTRP00000080387	ENSPTRP00000025426	Uncharacterized protein.	MutL homolog 1, colon cancer, nonpolyposis type 2.	0.995
CK820_G0047513	MLH3	ENSPTRP00000080387	ENSPTRP00000076885	Uncharacterized protein.	MLH3 isoform 1.	0.819
CK820_G0047513	MSH4	ENSPTRP00000080387	ENSPTRP00000084312	Uncharacterized protein.	MSH4 isoform 1.	0.847
CK820_G0047513	MSH5	ENSPTRP00000080387	ENSPTRP00000030697	Uncharacterized protein.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.894
CK820_G0047513	PMS1	ENSPTRP00000080387	ENSPTRP00000066616	Uncharacterized protein.	PMS1 homolog 1, mismatch repair system component.	0.845
CK820_G0047513	PMS2	ENSPTRP00000080387	ENSPTRP00000090549	Uncharacterized protein.	PMS1 homolog 2, mismatch repair system component.	0.543
CK820_G0052740	ATM	ENSPTRP00000032326	ENSPTRP00000054216	PMS2 isoform 6.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.721
CK820_G0052740	CK820_G0047513	ENSPTRP00000032326	ENSPTRP00000080387	PMS2 isoform 6.	Uncharacterized protein.	0.544