PATR-DOB protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

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empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD4	HLA-DOA	ENSPTRP00000054833	ENSPTRP00000030784	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	0.476
CD4	HLA-DPA1	ENSPTRP00000054833	ENSPTRP00000030785	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family.	0.935
CD4	HLA-DQA1	ENSPTRP00000054833	ENSPTRP00000055403	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	HLA-DQA2 isoform 1; Belongs to the MHC class II family.	0.936
CD4	HLA-DQA2	ENSPTRP00000054833	ENSPTRP00000030767	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Major histocompatibility complex, class II, DQ alpha 2.	0.921
CD4	HLA-DQB1	ENSPTRP00000054833	ENSPTRP00000030768	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3.	0.953
CD4	LOC104006793	ENSPTRP00000054833	ENSPTRP00000054452	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	HLA class II histocompatibility antigen, DR beta 3 chain precursor.	0.934
CD4	MAMU-DMA	ENSPTRP00000054833	ENSPTRP00000030781	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	HLA class II histocompatibility antigen, DM alpha chain isoform X1.	0.914
CD4	PATR-DMB	ENSPTRP00000054833	ENSPTRP00000030778	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	HLA-DMB isoform 5.	0.906
CD4	PATR-DOB	ENSPTRP00000054833	ENSPTRP00000030772	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	Patr class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM.	0.932
CD4	PATR-DRA	ENSPTRP00000054833	ENSPTRP00000030766	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	MHC class II protein; Belongs to the MHC class II family.	0.974
HLA-DOA	CD4	ENSPTRP00000030784	ENSPTRP00000054833	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	T-cell surface glycoprotein CD4; Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kina [...]	0.476
HLA-DOA	HLA-DPA1	ENSPTRP00000030784	ENSPTRP00000030785	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	Major histocompatibility complex, class II, DP alpha 1; Belongs to the MHC class II family.	0.988
HLA-DOA	HLA-DQA1	ENSPTRP00000030784	ENSPTRP00000055403	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	HLA-DQA2 isoform 1; Belongs to the MHC class II family.	0.962
HLA-DOA	HLA-DQA2	ENSPTRP00000030784	ENSPTRP00000030767	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	Major histocompatibility complex, class II, DQ alpha 2.	0.962
HLA-DOA	HLA-DQB1	ENSPTRP00000030784	ENSPTRP00000030768	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DQ beta 1 chain isoform X3.	0.964
HLA-DOA	LOC104006793	ENSPTRP00000030784	ENSPTRP00000054452	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DR beta 3 chain precursor.	0.964
HLA-DOA	MAMU-DMA	ENSPTRP00000030784	ENSPTRP00000030781	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	HLA class II histocompatibility antigen, DM alpha chain isoform X1.	0.967
HLA-DOA	PATR-DMB	ENSPTRP00000030784	ENSPTRP00000030778	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	HLA-DMB isoform 5.	0.994
HLA-DOA	PATR-DOB	ENSPTRP00000030784	ENSPTRP00000030772	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	Patr class II histocompatibility antigen, DO beta chain; Important modulator in the HLA class II restricted antigen presentation pathway by interaction with the HLA-DM molecule in B- cells. Modifies peptide exchange activity of HLA-DM.	0.992
HLA-DOA	PATR-DRA	ENSPTRP00000030784	ENSPTRP00000030766	Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family.	MHC class II protein; Belongs to the MHC class II family.	0.923