STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FKBP5Peptidylprolyl isomerase. (457 aa)    
Predicted Functional Partners:
HSP90AA1
Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]
   
 0.997
NR3C1
NR3C1 isoform 5.
    
 0.974
HSP90AB1
HSP90AB1 isoform 1.
   
 0.972
FKBP4
Peptidylprolyl isomerase.
  
  
0.951
ENSPTRP00000067051
annotation not available
   
 0.914
ENSPTRP00000075643
Prostaglandin E synthase 3-like isoform X1.
   
 0.914
LOC104001457
Prostaglandin E synthase 3-like isoform X1.
   
 0.914
PTGES3
Prostaglandin E synthase 3.
   
 0.914
PHLPP1
PH domain and leucine rich repeat protein phosphatase 1.
    
 
 0.902
MTOR
Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.
    
 
 0.890
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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