STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TFAP2DTranscription factor AP-2 delta. (452 aa)    
Predicted Functional Partners:
ZCCHC3
Zinc finger, CCHC domain containing 3.
   
  
 0.886
SPATA4
Spermatogenesis-associated protein 4; May play a role in apoptosis regulation.
      
 0.884
AGPAT5
1-acylglycerol-3-phosphate O-acyltransferase 5 (Lysophosphatidic acid acyltransferase, epsilon).
      
 0.881
TFAP2A
Transcription factor AP-2 alpha.
  
 
0.743
DEFB123
Beta-defensin 123; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.742
PGK1
Phosphoglycerate kinase 1; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.
      
 0.702
KCTD1
KCTD1 isoform 1.
   
 0.640
ENSPTRP00000069907
annotation not available
   
 0.640
TFAP2B
Transcription factor AP-2 beta.
  
 
0.579
BCL2L1
BCL2L1 isoform 6.
      
 0.571
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.