HTR1B protein (Pan troglodytes) - STRING interaction network

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HTR1B

5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...] (390 aa)

Predicted Functional Partners:

GNG2

0.953

GNB1

0.953

GNAO1

0.905

GNB4

0.842

GNAI3

0.797

GNB3

0.797

GNAI1

0.797

GNAI2

0.794

GNG4

0.792

SLC6A4

0.779

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNAI1	GNAI2	ENSPTRP00000071974	ENSPTRP00000025802	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.973
GNAI1	GNAI3	ENSPTRP00000071974	ENSPTRP00000001821	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.985
GNAI1	GNAO1	ENSPTRP00000071974	ENSPTRP00000088044	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	G protein subunit alpha o1.	0.823
GNAI1	GNB1	ENSPTRP00000071974	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.998
GNAI1	GNB3	ENSPTRP00000071974	ENSPTRP00000045189	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	G protein subunit beta 3.	0.891
GNAI1	GNB4	ENSPTRP00000071974	ENSPTRP00000026924	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide binding protein (G protein), beta polypeptide 4.	0.957
GNAI1	GNG2	ENSPTRP00000071974	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.995
GNAI1	GNG4	ENSPTRP00000071974	ENSPTRP00000003602	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.949
GNAI1	HTR1B	ENSPTRP00000071974	ENSPTRP00000031384	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...]	0.797
GNAI2	GNAI1	ENSPTRP00000025802	ENSPTRP00000071974	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	0.973
GNAI2	GNAI3	ENSPTRP00000025802	ENSPTRP00000001821	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	0.992
GNAI2	GNAO1	ENSPTRP00000025802	ENSPTRP00000088044	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	G protein subunit alpha o1.	0.803
GNAI2	GNB1	ENSPTRP00000025802	ENSPTRP00000067330	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), beta polypeptide 1.	0.997
GNAI2	GNB3	ENSPTRP00000025802	ENSPTRP00000045189	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	G protein subunit beta 3.	0.901
GNAI2	GNB4	ENSPTRP00000025802	ENSPTRP00000026924	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide binding protein (G protein), beta polypeptide 4.	0.950
GNAI2	GNG2	ENSPTRP00000025802	ENSPTRP00000065345	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.956
GNAI2	GNG4	ENSPTRP00000025802	ENSPTRP00000003602	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.926
GNAI2	HTR1B	ENSPTRP00000025802	ENSPTRP00000031384	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	5-hydroxytryptamine receptor 1B; G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopami [...]	0.794
GNAI3	GNAI1	ENSPTRP00000001821	ENSPTRP00000071974	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1.	0.985
GNAI3	GNAI2	ENSPTRP00000001821	ENSPTRP00000025802	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3.	Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2.	0.992

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