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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LCA5Leber congenital amaurosis 5. (697 aa)    
Predicted Functional Partners:
RDH12
Retinol dehydrogenase 12; Belongs to the short-chain dehydrogenases/reductases (SDR) family.
      
 0.665
TULP1
Tubby-like protein; Belongs to the TUB family.
   
  
 0.664
LRAT
Lecithin retinol acyltransferase.
      
 0.663
AIPL1
AIPL1 isoform 2.
      
 0.650
GUCY2D
Guanylate cyclase.
      
 0.628
RPGRIP1
RPGR interacting protein 1.
      
 0.577
RPE65
Retinoid isomerohydrolase RPE65.
   
  
 0.527
IMPDH1
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.
      
 0.510
WDR90
WDR90 isoform 1.
    
   0.508
CEP290
CEP290 isoform 5.
      
 0.495
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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