ESR1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT1	ESR1	ENSPTRP00000082849	ENSPTRP00000031932	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.990
AKT1	ESR2	ENSPTRP00000082849	ENSPTRP00000010911	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Estrogen receptor 2.	0.968
AKT1	PGR	ENSPTRP00000082849	ENSPTRP00000007237	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.	0.512
AKT1	SP1	ENSPTRP00000082849	ENSPTRP00000008536	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Sp1 transcription factor.	0.404
AKT1	SRC	ENSPTRP00000082849	ENSPTRP00000076797	AKT1 isoform 3; Belongs to the protein kinase superfamily.	Tyrosine-protein kinase.	0.921
ESR1	AKT1	ENSPTRP00000031932	ENSPTRP00000082849	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	AKT1 isoform 3; Belongs to the protein kinase superfamily.	0.990
ESR1	ESR2	ENSPTRP00000031932	ENSPTRP00000010911	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Estrogen receptor 2.	0.999
ESR1	MED1	ENSPTRP00000031932	ENSPTRP00000015490	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.996
ESR1	NCOA1	ENSPTRP00000031932	ENSPTRP00000020127	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.997
ESR1	NCOA2	ENSPTRP00000031932	ENSPTRP00000069925	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.995
ESR1	NCOA3	ENSPTRP00000031932	ENSPTRP00000023375	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor coactivator.	0.999
ESR1	NCOR1	ENSPTRP00000031932	ENSPTRP00000075557	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Nuclear receptor corepressor 1.	0.996
ESR1	PGR	ENSPTRP00000031932	ENSPTRP00000007237	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Progesterone receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcriptional activator of several progesteron-dependent promoters in a variety of cell types. Involved in activation of SRC-dependent MAPK signaling on hormone stimulation.	0.989
ESR1	SP1	ENSPTRP00000031932	ENSPTRP00000008536	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Sp1 transcription factor.	0.997
ESR1	SRC	ENSPTRP00000031932	ENSPTRP00000076797	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	Tyrosine-protein kinase.	0.997
ESR2	AKT1	ENSPTRP00000010911	ENSPTRP00000082849	Estrogen receptor 2.	AKT1 isoform 3; Belongs to the protein kinase superfamily.	0.968
ESR2	ESR1	ENSPTRP00000010911	ENSPTRP00000031932	Estrogen receptor 2.	Estrogen receptor; The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues.	0.999
ESR2	MED1	ENSPTRP00000010911	ENSPTRP00000015490	Estrogen receptor 2.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.991
ESR2	NCOA1	ENSPTRP00000010911	ENSPTRP00000020127	Estrogen receptor 2.	Nuclear receptor coactivator.	0.994
ESR2	NCOA2	ENSPTRP00000010911	ENSPTRP00000069925	Estrogen receptor 2.	Nuclear receptor coactivator.	0.982