| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATXN3 | PINK1 | ENSPTRP00000044008 | ENSPTRP00000000500 | ATXN3 isoform 4. | PTEN induced putative kinase 1. | 0.413 |
| ATXN3 | PRKN | ENSPTRP00000044008 | ENSPTRP00000032068 | ATXN3 isoform 4. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.990 |
| ATXN3 | SNCA | ENSPTRP00000044008 | ENSPTRP00000090843 | ATXN3 isoform 4. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.503 |
| ATXN3 | UBC | ENSPTRP00000044008 | ENSPTRP00000050925 | ATXN3 isoform 4. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.950 |
| GPR37 | PRKN | ENSPTRP00000033642 | ENSPTRP00000032068 | G protein-coupled receptor 37. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.991 |
| GPR37 | SNCA | ENSPTRP00000033642 | ENSPTRP00000090843 | G protein-coupled receptor 37. | Alpha-synuclein; Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca(2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs [...] | 0.437 |
| GPR37 | SNCAIP | ENSPTRP00000033642 | ENSPTRP00000085224 | G protein-coupled receptor 37. | SNCAIP isoform 11. | 0.511 |
| MFN1 | MFN2 | ENSPTRP00000026922 | ENSPTRP00000000305 | MFN1 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | MFN2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.998 |
| MFN1 | PINK1 | ENSPTRP00000026922 | ENSPTRP00000000500 | MFN1 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | PTEN induced putative kinase 1. | 0.933 |
| MFN1 | PRKN | ENSPTRP00000026922 | ENSPTRP00000032068 | MFN1 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.997 |
| MFN1 | RHOT1 | ENSPTRP00000026922 | ENSPTRP00000093402 | MFN1 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. | 0.972 |
| MFN1 | TOMM70 | ENSPTRP00000026922 | ENSPTRP00000026165 | MFN1 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Translocase of outer mitochondrial membrane 70 homolog A. | 0.934 |
| MFN1 | UBC | ENSPTRP00000026922 | ENSPTRP00000050925 | MFN1 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.922 |
| MFN2 | MFN1 | ENSPTRP00000000305 | ENSPTRP00000026922 | MFN2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | MFN1 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | 0.998 |
| MFN2 | PINK1 | ENSPTRP00000000305 | ENSPTRP00000000500 | MFN2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | PTEN induced putative kinase 1. | 0.964 |
| MFN2 | PRKN | ENSPTRP00000000305 | ENSPTRP00000032068 | MFN2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. | 0.997 |
| MFN2 | RHOT1 | ENSPTRP00000000305 | ENSPTRP00000093402 | MFN2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. | 0.973 |
| MFN2 | TOMM70 | ENSPTRP00000000305 | ENSPTRP00000026165 | MFN2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Translocase of outer mitochondrial membrane 70 homolog A. | 0.934 |
| MFN2 | UBC | ENSPTRP00000000305 | ENSPTRP00000050925 | MFN2 isoform 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. | Polyubiquitin-C; [Ubiquitin]: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair [...] | 0.922 |
| PINK1 | ATXN3 | ENSPTRP00000000500 | ENSPTRP00000044008 | PTEN induced putative kinase 1. | ATXN3 isoform 4. | 0.413 |
