node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APAF1 | BAK1 | ENSPTRP00000042795 | ENSPTRP00000050271 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2-antagonist/killer 1. | 0.642 |
APAF1 | BAX | ENSPTRP00000042795 | ENSPTRP00000092787 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BAX isoform 7. | 0.626 |
APAF1 | BCL2 | ENSPTRP00000042795 | ENSPTRP00000090293 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2 apoptosis regulator. | 0.953 |
APAF1 | BCL2L1 | ENSPTRP00000042795 | ENSPTRP00000022903 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BCL2L1 isoform 6. | 0.895 |
APAF1 | CASP3 | ENSPTRP00000042795 | ENSPTRP00000054330 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.997 |
APAF1 | CASP9 | ENSPTRP00000042795 | ENSPTRP00000089496 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP9 isoform 4; Belongs to the peptidase C14A family. | 0.999 |
APAF1 | CYC1 | ENSPTRP00000042795 | ENSPTRP00000035371 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CYC1 isoform 2. | 0.544 |
APAF1 | CYCS | ENSPTRP00000042795 | ENSPTRP00000032465 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.999 |
APAF1 | HTRA2 | ENSPTRP00000042795 | ENSPTRP00000073790 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | HtrA serine peptidase 2. | 0.694 |
BAK1 | APAF1 | ENSPTRP00000050271 | ENSPTRP00000042795 | BCL2-antagonist/killer 1. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.642 |
BAK1 | BAX | ENSPTRP00000050271 | ENSPTRP00000092787 | BCL2-antagonist/killer 1. | BAX isoform 7. | 0.957 |
BAK1 | BCL2 | ENSPTRP00000050271 | ENSPTRP00000090293 | BCL2-antagonist/killer 1. | BCL2 apoptosis regulator. | 0.989 |
BAK1 | BCL2L1 | ENSPTRP00000050271 | ENSPTRP00000022903 | BCL2-antagonist/killer 1. | BCL2L1 isoform 6. | 0.994 |
BAK1 | CASP3 | ENSPTRP00000050271 | ENSPTRP00000054330 | BCL2-antagonist/killer 1. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.471 |
BAK1 | CASP9 | ENSPTRP00000050271 | ENSPTRP00000089496 | BCL2-antagonist/killer 1. | CASP9 isoform 4; Belongs to the peptidase C14A family. | 0.507 |
BAK1 | CYCS | ENSPTRP00000050271 | ENSPTRP00000032465 | BCL2-antagonist/killer 1. | Cytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity). | 0.960 |
BAX | APAF1 | ENSPTRP00000092787 | ENSPTRP00000042795 | BAX isoform 7. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.626 |
BAX | BAK1 | ENSPTRP00000092787 | ENSPTRP00000050271 | BAX isoform 7. | BCL2-antagonist/killer 1. | 0.957 |
BAX | BCL2 | ENSPTRP00000092787 | ENSPTRP00000090293 | BAX isoform 7. | BCL2 apoptosis regulator. | 0.971 |
BAX | BCL2L1 | ENSPTRP00000092787 | ENSPTRP00000022903 | BAX isoform 7. | BCL2L1 isoform 6. | 0.946 |