STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EEPD1Endonuclease/exonuclease/phosphatase family domain containing 1. (569 aa)    
Predicted Functional Partners:
IWS1
Interacts with SUPT6H, CTD assembly factor 1.
   
 0.901
SSRP1
FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...]
   
 0.876
LEO1
Leo1, Paf1/RNA polymerase II complex component, homolog.
   
 0.832
SUPT16H
SPT16 homolog, facilitates chromatin remodeling subunit.
   
 0.796
ENSPTRP00000061528
annotation not available
   
 0.796
SUPT4H1
Transcription elongation factor SPT4; Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II; Belongs to the SPT4 family.
    
 0.787
POLR2G
POLR2G isoform 2.
    
 0.746
POLR2E
Polymerase (RNA) II (DNA directed) polypeptide E, 25kDa.
    
 0.735
POLR2D
Polymerase (RNA) II (DNA directed) polypeptide D.
    
 0.726
CDC73
Cell division cycle 73, Paf1/RNA polymerase II complex component, homolog.
   
 0.704
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.