node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTRC | CUL3 | ENSPTRP00000077054 | ENSPTRP00000022190 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | CUL3 isoform 2; Belongs to the cullin family. | 0.889 |
BTRC | GLI1 | ENSPTRP00000077054 | ENSPTRP00000078209 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | GLI family zinc finger 1. | 0.964 |
BTRC | GLI2 | ENSPTRP00000077054 | ENSPTRP00000040313 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | GLI family zinc finger 2. | 0.966 |
BTRC | GLI3 | ENSPTRP00000077054 | ENSPTRP00000032656 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] | 0.978 |
BTRC | SUFU | ENSPTRP00000077054 | ENSPTRP00000073892 | Beta-transducin repeat containing E3 ubiquitin protein ligase. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.585 |
CUL3 | BTRC | ENSPTRP00000022190 | ENSPTRP00000077054 | CUL3 isoform 2; Belongs to the cullin family. | Beta-transducin repeat containing E3 ubiquitin protein ligase. | 0.889 |
CUL3 | GLI1 | ENSPTRP00000022190 | ENSPTRP00000078209 | CUL3 isoform 2; Belongs to the cullin family. | GLI family zinc finger 1. | 0.959 |
CUL3 | GLI2 | ENSPTRP00000022190 | ENSPTRP00000040313 | CUL3 isoform 2; Belongs to the cullin family. | GLI family zinc finger 2. | 0.961 |
CUL3 | GLI3 | ENSPTRP00000022190 | ENSPTRP00000032656 | CUL3 isoform 2; Belongs to the cullin family. | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] | 0.959 |
CUL3 | SPOP | ENSPTRP00000022190 | ENSPTRP00000015931 | CUL3 isoform 2; Belongs to the cullin family. | Speckle type BTB/POZ protein. | 0.999 |
CUL3 | SPOPL | ENSPTRP00000022190 | ENSPTRP00000021390 | CUL3 isoform 2; Belongs to the cullin family. | Speckle type BTB/POZ protein like. | 0.997 |
CUL3 | SUFU | ENSPTRP00000022190 | ENSPTRP00000073892 | CUL3 isoform 2; Belongs to the cullin family. | Suppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] | 0.560 |
GLI1 | BTRC | ENSPTRP00000078209 | ENSPTRP00000077054 | GLI family zinc finger 1. | Beta-transducin repeat containing E3 ubiquitin protein ligase. | 0.964 |
GLI1 | CUL3 | ENSPTRP00000078209 | ENSPTRP00000022190 | GLI family zinc finger 1. | CUL3 isoform 2; Belongs to the cullin family. | 0.959 |
GLI1 | GLI2 | ENSPTRP00000078209 | ENSPTRP00000040313 | GLI family zinc finger 1. | GLI family zinc finger 2. | 0.992 |
GLI1 | GLI3 | ENSPTRP00000078209 | ENSPTRP00000032656 | GLI family zinc finger 1. | Transcriptional repressor GLI3R; Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in re [...] | 0.987 |
GLI1 | PRKACA | ENSPTRP00000078209 | ENSPTRP00000018062 | GLI family zinc finger 1. | PRKACA isoform 7; Belongs to the protein kinase superfamily. | 0.958 |
GLI1 | PRKACB | ENSPTRP00000078209 | ENSPTRP00000042330 | GLI family zinc finger 1. | Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily. | 0.958 |
GLI1 | PRKACG | ENSPTRP00000078209 | ENSPTRP00000035898 | GLI family zinc finger 1. | Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily. | 0.958 |
GLI1 | SPOP | ENSPTRP00000078209 | ENSPTRP00000015931 | GLI family zinc finger 1. | Speckle type BTB/POZ protein. | 0.989 |