| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CBS | FLAD1 | ENSPTRP00000024013 | ENSPTRP00000002354 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | FAD synthase; Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme. In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily. | 0.601 |
| CBS | POR-2 | ENSPTRP00000024013 | ENSPTRP00000033034 | Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.643 |
| CYB5A | CYP17A1 | ENSPTRP00000017180 | ENSPTRP00000069568 | Cytochrome b5 type A (Microsomal); Belongs to the cytochrome b5 family. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.800 |
| CYB5A | CYP1A2 | ENSPTRP00000017180 | ENSPTRP00000070670 | Cytochrome b5 type A (Microsomal); Belongs to the cytochrome b5 family. | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.556 |
| CYB5A | CYP2E1 | ENSPTRP00000017180 | ENSPTRP00000005465 | Cytochrome b5 type A (Microsomal); Belongs to the cytochrome b5 family. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.597 |
| CYB5A | POR-2 | ENSPTRP00000017180 | ENSPTRP00000033034 | Cytochrome b5 type A (Microsomal); Belongs to the cytochrome b5 family. | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.799 |
| CYB5B | CYP17A1 | ENSPTRP00000014140 | ENSPTRP00000069568 | Cytochrome b5 type B (Outer mitochondrial membrane); Belongs to the cytochrome b5 family. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.785 |
| CYB5B | CYP1A2 | ENSPTRP00000014140 | ENSPTRP00000070670 | Cytochrome b5 type B (Outer mitochondrial membrane); Belongs to the cytochrome b5 family. | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.440 |
| CYB5B | CYP2E1 | ENSPTRP00000014140 | ENSPTRP00000005465 | Cytochrome b5 type B (Outer mitochondrial membrane); Belongs to the cytochrome b5 family. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.524 |
| CYB5B | POR-2 | ENSPTRP00000014140 | ENSPTRP00000033034 | Cytochrome b5 type B (Outer mitochondrial membrane); Belongs to the cytochrome b5 family. | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.822 |
| CYP17A1 | CYB5A | ENSPTRP00000069568 | ENSPTRP00000017180 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome b5 type A (Microsomal); Belongs to the cytochrome b5 family. | 0.800 |
| CYP17A1 | CYB5B | ENSPTRP00000069568 | ENSPTRP00000014140 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome b5 type B (Outer mitochondrial membrane); Belongs to the cytochrome b5 family. | 0.785 |
| CYP17A1 | CYP1A2 | ENSPTRP00000069568 | ENSPTRP00000070670 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | 0.920 |
| CYP17A1 | CYP2E1 | ENSPTRP00000069568 | ENSPTRP00000005465 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.920 |
| CYP17A1 | POR-2 | ENSPTRP00000069568 | ENSPTRP00000033034 | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.686 |
| CYP1A2 | CYB5A | ENSPTRP00000070670 | ENSPTRP00000017180 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cytochrome b5 type A (Microsomal); Belongs to the cytochrome b5 family. | 0.556 |
| CYP1A2 | CYB5B | ENSPTRP00000070670 | ENSPTRP00000014140 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cytochrome b5 type B (Outer mitochondrial membrane); Belongs to the cytochrome b5 family. | 0.440 |
| CYP1A2 | CYP17A1 | ENSPTRP00000070670 | ENSPTRP00000069568 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Steroid 17-alpha-hydroxylase/17,20 lyase; A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, [...] | 0.920 |
| CYP1A2 | CYP2E1 | ENSPTRP00000070670 | ENSPTRP00000005465 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | Cytochrome P450 family 2 subfamily E member 1; Belongs to the cytochrome P450 family. | 0.952 |
| CYP1A2 | POR-2 | ENSPTRP00000070670 | ENSPTRP00000033034 | Cytochrome P450 family 1 subfamily A member 2; Belongs to the cytochrome P450 family. | NADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. | 0.659 |
