MDH2 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATP5F1A	ATP5F1B	ENSPTRP00000064836	ENSPTRP00000008686	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.999
ATP5F1A	CS	ENSPTRP00000064836	ENSPTRP00000008664	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	Citrate synthase, mitochondrial isoform X1.	0.720
ATP5F1A	ENSPTRP00000066534	ENSPTRP00000064836	ENSPTRP00000066534	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	annotation not available	0.627
ATP5F1A	ENSPTRP00000087640	ENSPTRP00000064836	ENSPTRP00000087640	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	annotation not available	0.901
ATP5F1A	FH	ENSPTRP00000064836	ENSPTRP00000003656	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	Fumarate hydratase.	0.788
ATP5F1A	GOT1	ENSPTRP00000064836	ENSPTRP00000004968	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	0.410
ATP5F1A	GOT2	ENSPTRP00000064836	ENSPTRP00000013976	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	Aspartate aminotransferase.	0.633
ATP5F1A	MDH1	ENSPTRP00000064836	ENSPTRP00000088176	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	Malate dehydrogenase.	0.724
ATP5F1A	MDH2	ENSPTRP00000064836	ENSPTRP00000033039	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	Malate dehydrogenase.	0.977
ATP5F1B	ATP5F1A	ENSPTRP00000008686	ENSPTRP00000064836	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	0.999
ATP5F1B	CS	ENSPTRP00000008686	ENSPTRP00000008664	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Citrate synthase, mitochondrial isoform X1.	0.840
ATP5F1B	ENSPTRP00000066534	ENSPTRP00000008686	ENSPTRP00000066534	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	annotation not available	0.486
ATP5F1B	ENSPTRP00000087640	ENSPTRP00000008686	ENSPTRP00000087640	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	annotation not available	0.999
ATP5F1B	FH	ENSPTRP00000008686	ENSPTRP00000003656	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Fumarate hydratase.	0.795
ATP5F1B	GOT2	ENSPTRP00000008686	ENSPTRP00000013976	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Aspartate aminotransferase.	0.486
ATP5F1B	MDH1	ENSPTRP00000008686	ENSPTRP00000088176	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Malate dehydrogenase.	0.547
ATP5F1B	MDH2	ENSPTRP00000008686	ENSPTRP00000033039	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	Malate dehydrogenase.	0.989
CS	ATP5F1A	ENSPTRP00000008664	ENSPTRP00000064836	Citrate synthase, mitochondrial isoform X1.	ATP synthase subunit alpha, mitochondrial; Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the [...]	0.720
CS	ATP5F1B	ENSPTRP00000008664	ENSPTRP00000008686	Citrate synthase, mitochondrial isoform X1.	ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane.	0.840
CS	ENSPTRP00000066534	ENSPTRP00000008664	ENSPTRP00000066534	Citrate synthase, mitochondrial isoform X1.	annotation not available	0.723