STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTPN12Tyrosine-protein phosphatase non-receptor type 12; Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. (780 aa)    
Predicted Functional Partners:
CK820_G0036696
PSTPIP1 isoform 2.
   
 
 0.939
PXN
PXN isoform 20.
   
 0.939
PXN-2
PXN isoform 9.
   
 0.939
SHC1
SHC (Src homology 2 domain containing) transforming protein 1.
   
 0.922
EGFR
Receptor protein-tyrosine kinase.
    
 0.911
BCAR1
BCAR1 scaffold protein, Cas family member.
    
 
 0.896
CSK
Tyrosine-protein kinase.
   
 0.883
ITGA9
Integrin subunit alpha 9; Belongs to the integrin alpha chain family.
   
 0.870
PSTPIP2
Proline-serine-threonine phosphatase interacting protein 2.
   
 
 0.842
ERBB2
Receptor protein-tyrosine kinase.
    
 0.817
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.