HGF protein (Pan troglodytes) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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gene neighborhood

gene co-occurrence

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Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CRK	GAB1	ENSPTRP00000083173	ENSPTRP00000028277	V-crk sarcoma virus CT10 oncogene homolog (Avian).	GRB2-associated-binding protein 1.	0.994
CRK	HGF	ENSPTRP00000083173	ENSPTRP00000072810	V-crk sarcoma virus CT10 oncogene homolog (Avian).	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.837
CRK	MET	ENSPTRP00000083173	ENSPTRP00000083162	V-crk sarcoma virus CT10 oncogene homolog (Avian).	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.893
CRK	MST1R	ENSPTRP00000083173	ENSPTRP00000025788	V-crk sarcoma virus CT10 oncogene homolog (Avian).	Macrophage stimulating 1 receptor.	0.582
CRK	PIK3CA	ENSPTRP00000083173	ENSPTRP00000084763	V-crk sarcoma virus CT10 oncogene homolog (Avian).	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.793
GAB1	CRK	ENSPTRP00000028277	ENSPTRP00000083173	GRB2-associated-binding protein 1.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.994
GAB1	HGF	ENSPTRP00000028277	ENSPTRP00000072810	GRB2-associated-binding protein 1.	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	0.883
GAB1	MET	ENSPTRP00000028277	ENSPTRP00000083162	GRB2-associated-binding protein 1.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.992
GAB1	MST1R	ENSPTRP00000028277	ENSPTRP00000025788	GRB2-associated-binding protein 1.	Macrophage stimulating 1 receptor.	0.831
GAB1	PIK3CA	ENSPTRP00000028277	ENSPTRP00000084763	GRB2-associated-binding protein 1.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.980
HGF	CRK	ENSPTRP00000072810	ENSPTRP00000083173	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.837
HGF	GAB1	ENSPTRP00000072810	ENSPTRP00000028277	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	GRB2-associated-binding protein 1.	0.883
HGF	HPN	ENSPTRP00000072810	ENSPTRP00000018535	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	HPN isoform 1; Belongs to the peptidase S1 family.	0.889
HGF	MET	ENSPTRP00000072810	ENSPTRP00000083162	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Hepatocyte growth factor receptor; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of thes [...]	0.997
HGF	MST1R	ENSPTRP00000072810	ENSPTRP00000025788	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Macrophage stimulating 1 receptor.	0.885
HGF	PIK3CA	ENSPTRP00000072810	ENSPTRP00000084763	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.	0.844
HGF	PTPN1	ENSPTRP00000072810	ENSPTRP00000043532	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Tyrosine-protein phosphatase non-receptor type.	0.834
HGF	SPINT1	ENSPTRP00000072810	ENSPTRP00000011835	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	SPINT1 isoform 2.	0.941
HGF	SPINT2	ENSPTRP00000072810	ENSPTRP00000065532	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	T0106202 isoform 2.	0.916
HGF	STAT3	ENSPTRP00000072810	ENSPTRP00000091410	Hepatocyte growth factor; Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Belongs to the peptidase S1 family. Plasminogen subfamily.	Signal transducer and activator of transcription.	0.933