| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AGTR1 | SERPINE1 | ENSPTRP00000063456 | ENSPTRP00000033420 | Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system (By similarity); Belongs to the G-protein coupled receptor 1 family. | Serpin family E member 1; Belongs to the serpin family. | 0.929 |
| F3 | PLAT | ENSPTRP00000040007 | ENSPTRP00000034599 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | Plasminogen activator; Belongs to the peptidase S1 family. | 0.790 |
| F3 | PLAU | ENSPTRP00000040007 | ENSPTRP00000004595 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | Plasminogen activator, urokinase. | 0.726 |
| F3 | PLG | ENSPTRP00000040007 | ENSPTRP00000032051 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.848 |
| F3 | SERPINE1 | ENSPTRP00000040007 | ENSPTRP00000033420 | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | Serpin family E member 1; Belongs to the serpin family. | 0.671 |
| ORM2 | SERPINE1 | ENSPTRP00000036363 | ENSPTRP00000033420 | Alpha-1-acid glycoprotein; Functions as transport protein in the blood stream. Belongs to the calycin superfamily. Lipocalin family. | Serpin family E member 1; Belongs to the serpin family. | 0.693 |
| PLAT | F3 | ENSPTRP00000034599 | ENSPTRP00000040007 | Plasminogen activator; Belongs to the peptidase S1 family. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.790 |
| PLAT | PLAU | ENSPTRP00000034599 | ENSPTRP00000004595 | Plasminogen activator; Belongs to the peptidase S1 family. | Plasminogen activator, urokinase. | 0.570 |
| PLAT | PLAUR | ENSPTRP00000034599 | ENSPTRP00000054428 | Plasminogen activator; Belongs to the peptidase S1 family. | Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). | 0.944 |
| PLAT | PLG | ENSPTRP00000034599 | ENSPTRP00000032051 | Plasminogen activator; Belongs to the peptidase S1 family. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.987 |
| PLAT | SERPINE1 | ENSPTRP00000034599 | ENSPTRP00000033420 | Plasminogen activator; Belongs to the peptidase S1 family. | Serpin family E member 1; Belongs to the serpin family. | 0.998 |
| PLAT | TGFB1 | ENSPTRP00000034599 | ENSPTRP00000018930 | Plasminogen activator; Belongs to the peptidase S1 family. | Transforming growth factor beta; Belongs to the TGF-beta family. | 0.400 |
| PLAT | VTN | ENSPTRP00000034599 | ENSPTRP00000015217 | Plasminogen activator; Belongs to the peptidase S1 family. | VTN isoform 1. | 0.641 |
| PLAU | F3 | ENSPTRP00000004595 | ENSPTRP00000040007 | Plasminogen activator, urokinase. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.726 |
| PLAU | PLAT | ENSPTRP00000004595 | ENSPTRP00000034599 | Plasminogen activator, urokinase. | Plasminogen activator; Belongs to the peptidase S1 family. | 0.570 |
| PLAU | PLAUR | ENSPTRP00000004595 | ENSPTRP00000054428 | Plasminogen activator, urokinase. | Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). | 0.999 |
| PLAU | PLG | ENSPTRP00000004595 | ENSPTRP00000032051 | Plasminogen activator, urokinase. | Plasminogen; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated b [...] | 0.972 |
| PLAU | SERPINE1 | ENSPTRP00000004595 | ENSPTRP00000033420 | Plasminogen activator, urokinase. | Serpin family E member 1; Belongs to the serpin family. | 0.998 |
| PLAU | VTN | ENSPTRP00000004595 | ENSPTRP00000015217 | Plasminogen activator, urokinase. | VTN isoform 1. | 0.729 |
| PLAUR | PLAT | ENSPTRP00000054428 | ENSPTRP00000034599 | Urokinase plasminogen activator surface receptor; Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form (By similarity). | Plasminogen activator; Belongs to the peptidase S1 family. | 0.944 |
