STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MYL10Uncharacterized protein; Myosin, light chain 10, regulatory (226 aa)    
Predicted Functional Partners:
ROCK2
Rho-associated protein kinase 2 isoform x1; Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity
    
 0.959
MYLK
Myosin light chain kinase, smooth muscle isoform x2; Uncharacterized protein; Myosin light chain kinase
   
 0.948
MYH10
Myosin, heavy chain 10, non-muscle; Uncharacterized protein ; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family
   
 0.940
ROCK1
Rho-associated protein kinase 1 isoform x1; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, TPPP, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stre [...]
    
 0.914
PPP1R12A
Protein phosphatase 1 regulatory subunit 12a isoform x1; Protein phosphatase 1, regulatory subunit 12A
    
 0.911
MYH14
Myosin heavy chain 9/10/11/14; Myosin, heavy chain 14, non-muscle; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family
   
 0.901
MYL1
Uncharacterized protein; Myosin, light chain 1, alkali skeletal, fast; Uncharacterized protein
   
 0.893
ACTB
Actin, cytoplasmic 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells
   
 0.884
CDC42BPB
Serine/threonine-protein kinase mrck beta isoform x1; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family
    
 0.879
MYH6
Myosin heavy chain 6/7; Myosin, heavy chain 6, cardiac muscle, alpha; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family
   
 0.877
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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