STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
EPHB6Ephrin type-B receptor 6; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2 (By similarity). (1020 aa)    
Predicted Functional Partners:
EFNB3
EFNB3 isoform 1; Belongs to the ephrin family.
   
 0.995
EFNB1
EFNB1 isoform 1; Belongs to the ephrin family.
   
 0.992
EFNB2
EFNB2 isoform 1; Belongs to the ephrin family.
   
 0.991
NGEF
Neuronal guanine nucleotide exchange factor.
    
 0.918
RASA1
RAS p21 protein activator (GTPase activating protein) 1.
   
  0.911
ABL1
Tyrosine-protein kinase.
   
0.906
EFNA1
EFNA1 isoform 2; Belongs to the ephrin family.
   
 0.843
EFNA5
EFNA5 isoform 1; Belongs to the ephrin family.
   
 0.831
EFNA3
Ephrin-A3 isoform X1.
   
 0.823
EFNA4
EFNA4 isoform 1; Belongs to the ephrin family.
   
 0.802
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.