| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| APAF1 | BID | ENSPTRP00000042795 | ENSPTRP00000024179 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | 0.460 |
| APAF1 | BIRC2 | ENSPTRP00000042795 | ENSPTRP00000007251 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Baculoviral IAP repeat containing 2. | 0.739 |
| APAF1 | CASP10 | ENSPTRP00000042795 | ENSPTRP00000063394 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP10 isoform 4; Belongs to the peptidase C14A family. | 0.847 |
| APAF1 | CASP2 | ENSPTRP00000042795 | ENSPTRP00000033919 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.773 |
| APAF1 | CASP3 | ENSPTRP00000042795 | ENSPTRP00000054330 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.996 |
| APAF1 | CASP8 | ENSPTRP00000042795 | ENSPTRP00000021879 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.857 |
| APAF1 | CRADD | ENSPTRP00000042795 | ENSPTRP00000087931 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | CASP2 and RIPK1 domain containing adaptor with death domain. | 0.484 |
| APAF1 | PIDD1 | ENSPTRP00000042795 | ENSPTRP00000082395 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Leucine-rich repeats and death domain containing. | 0.660 |
| BID | APAF1 | ENSPTRP00000024179 | ENSPTRP00000042795 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.460 |
| BID | CASP10 | ENSPTRP00000024179 | ENSPTRP00000063394 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | CASP10 isoform 4; Belongs to the peptidase C14A family. | 0.990 |
| BID | CASP2 | ENSPTRP00000024179 | ENSPTRP00000033919 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.963 |
| BID | CASP3 | ENSPTRP00000024179 | ENSPTRP00000054330 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.832 |
| BID | CASP8 | ENSPTRP00000024179 | ENSPTRP00000021879 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.994 |
| BID | CRADD | ENSPTRP00000024179 | ENSPTRP00000087931 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | CASP2 and RIPK1 domain containing adaptor with death domain. | 0.434 |
| BID | PIDD1 | ENSPTRP00000024179 | ENSPTRP00000082395 | BH3-interacting domain death agonist; Counters the protective effect of Bcl-2. | Leucine-rich repeats and death domain containing. | 0.928 |
| BIRC2 | APAF1 | ENSPTRP00000007251 | ENSPTRP00000042795 | Baculoviral IAP repeat containing 2. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.739 |
| BIRC2 | CASP10 | ENSPTRP00000007251 | ENSPTRP00000063394 | Baculoviral IAP repeat containing 2. | CASP10 isoform 4; Belongs to the peptidase C14A family. | 0.654 |
| BIRC2 | CASP2 | ENSPTRP00000007251 | ENSPTRP00000033919 | Baculoviral IAP repeat containing 2. | Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.675 |
| BIRC2 | CASP3 | ENSPTRP00000007251 | ENSPTRP00000054330 | Baculoviral IAP repeat containing 2. | Caspase-3 subunit p12; Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage (By similarity). Belongs to the peptidase C14A family. | 0.995 |
| BIRC2 | CASP8 | ENSPTRP00000007251 | ENSPTRP00000021879 | Baculoviral IAP repeat containing 2. | Caspase 8, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. | 0.914 |
