STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1203 aa)    
Predicted Functional Partners:
HSP90AA1
Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]
    
 0.961
CALM3
Calmodulin 1 (Phosphorylase kinase, delta); Belongs to the calmodulin family.
    
 0.948
CALML5
Calmodulin like 5.
    
 0.938
AKT1
AKT1 isoform 3; Belongs to the protein kinase superfamily.
    
 0.933
CALML3
Calmodulin like 3; Belongs to the calmodulin family.
    
 0.925
NOSIP
Nitric oxide synthase-interacting protein; Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity; Belongs to the NOSIP family.
    
 0.909
HSP90AB1
HSP90AB1 isoform 1.
    
 0.898
CALML6
Calmodulin like 6.
    
 0.892
CALML4
Calmodulin like 4.
    
 0.892
CALM1
CALM1 isoform 3; Belongs to the calmodulin family.
    
 0.888
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.