DEFB103A protein (Pan troglodytes) - STRING interaction network

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DEFA4	DEFA5	ENSPTRP00000034186	ENSPTRP00000072107	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	0.957
DEFA4	DEFA6	ENSPTRP00000034186	ENSPTRP00000086584	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	Defensin-6; Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria; Belongs to the alpha-defensin family.	0.930
DEFA4	DEFB1	ENSPTRP00000034186	ENSPTRP00000034184	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.	0.750
DEFA4	DEFB103A	ENSPTRP00000034186	ENSPTRP00000034200	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	Beta-defensin 103A; Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria; Belongs to the beta-defensin family.	0.945
DEFA4	DEFB104	ENSPTRP00000034186	ENSPTRP00000034195	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	Beta-defensin 104A; Has antimicrobial activity; Belongs to the beta-defensin family.	0.444
DEFA4	DEFB105A	ENSPTRP00000034186	ENSPTRP00000034193	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	Beta-defensin 105A; Has antimicrobial activity; Belongs to the beta-defensin family.	0.444
DEFA4	DEFB106A	ENSPTRP00000034186	ENSPTRP00000034194	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	Beta-defensin 106A; Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2.	0.444
DEFA4	DEFB107A	ENSPTRP00000034186	ENSPTRP00000034191	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	Beta-defensin 107A; Has antibacterial activity; Belongs to the beta-defensin family.	0.444
DEFA4	DEFB4A	ENSPTRP00000034186	ENSPTRP00000072908	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	Beta-defensin 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells; Belongs to the beta-defensin family. LAP/TAP subfamily.	0.951
DEFA4	LOC107973208	ENSPTRP00000034186	ENSPTRP00000079419	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	Neutrophil defensin 1; Has antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane (By similarity); Belongs to the alpha-defensin family.	0.941
DEFA5	DEFA4	ENSPTRP00000072107	ENSPTRP00000034186	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	Neutrophil defensin 4; Has antimicrobial activity against Gram-negative bacteria, and to a lesser extent also against Gram-positive bacteria and fungi. Inhibits corticotropin (ACTH)-stimulated corticosterone production (By similarity).	0.957
DEFA5	DEFA6	ENSPTRP00000072107	ENSPTRP00000086584	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	Defensin-6; Has very low antimicrobial activity against Gram-negative and Gram-positive bacteria; Belongs to the alpha-defensin family.	0.998
DEFA5	DEFB1	ENSPTRP00000072107	ENSPTRP00000034184	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	Beta-defensin 1; Has bactericidal activity. May act as a ligand for C-C chemokine receptor CCR6. Positively regulates the sperm motility and bactericidal activity in a CCR6-dependent manner. Binds to CCR6 and triggers Ca2+ mobilization in the sperm which is important for its motility.	0.812
DEFA5	DEFB103A	ENSPTRP00000072107	ENSPTRP00000034200	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	Beta-defensin 103A; Exhibits antimicrobial activity against Gram-positive and Gram-negative bacteria; Belongs to the beta-defensin family.	0.974
DEFA5	DEFB104	ENSPTRP00000072107	ENSPTRP00000034195	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	Beta-defensin 104A; Has antimicrobial activity; Belongs to the beta-defensin family.	0.716
DEFA5	DEFB105A	ENSPTRP00000072107	ENSPTRP00000034193	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	Beta-defensin 105A; Has antimicrobial activity; Belongs to the beta-defensin family.	0.725
DEFA5	DEFB106A	ENSPTRP00000072107	ENSPTRP00000034194	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	Beta-defensin 106A; Has antibacterial activity. Acts as a ligand for C-C chemokine receptor CCR2.	0.728
DEFA5	DEFB107A	ENSPTRP00000072107	ENSPTRP00000034191	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	Beta-defensin 107A; Has antibacterial activity; Belongs to the beta-defensin family.	0.723
DEFA5	DEFB4A	ENSPTRP00000072107	ENSPTRP00000072908	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	Beta-defensin 4A; Exhibits antimicrobial activity against Gram-negative bacteria and Gram-positive bacteria. May act as a ligand for C-C chemokine receptor CCR6. Binds to CCR6 and induces chemotactic activity of CCR6-expressing cells; Belongs to the beta-defensin family. LAP/TAP subfamily.	0.954
DEFA5	LOC107973208	ENSPTRP00000072107	ENSPTRP00000079419	Defensin-5; Has antimicrobial activity against Gram-negative and Gram- positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane. All DEFA5 peptides exert antimicrobial activities, but their potency is affected by peptide processing (By similarity); Belongs to the alpha-defensin family.	Neutrophil defensin 1; Has antibacterial, fungicide and antiviral activities. Has antimicrobial activity against Gram-negative and Gram-positive bacteria. Defensins are thought to kill microbes by permeabilizing their plasma membrane (By similarity); Belongs to the alpha-defensin family.	0.921