| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACER1 | ACER3 | ENSPTRP00000017621 | ENSPTRP00000007035 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.428 |
| ACER1 | ASAH1 | ENSPTRP00000017621 | ENSPTRP00000063559 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | 0.963 |
| ACER1 | ASAH2 | ENSPTRP00000017621 | ENSPTRP00000090739 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Neutral ceramidase. | 0.954 |
| ACER1 | CERK | ENSPTRP00000017621 | ENSPTRP00000087585 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Ceramide kinase. | 0.960 |
| ACER1 | DEGS1 | ENSPTRP00000017621 | ENSPTRP00000003391 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Degenerative spermatocyte homolog 1, lipid desaturase. | 0.919 |
| ACER1 | GALC | ENSPTRP00000017621 | ENSPTRP00000011226 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Galactosylceramidase. | 0.921 |
| ACER1 | GBA2 | ENSPTRP00000017621 | ENSPTRP00000035782 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. | 0.921 |
| ACER1 | SMPD1 | ENSPTRP00000017621 | ENSPTRP00000005756 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. | 0.923 |
| ACER1 | SPHK1 | ENSPTRP00000017621 | ENSPTRP00000052717 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine kinase 1. | 0.952 |
| ACER1 | SPHK2 | ENSPTRP00000017621 | ENSPTRP00000019290 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine kinase 2. | 0.953 |
| ACER3 | ACER1 | ENSPTRP00000007035 | ENSPTRP00000017621 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.428 |
| ACER3 | ASAH1 | ENSPTRP00000007035 | ENSPTRP00000063559 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | 0.970 |
| ACER3 | ASAH2 | ENSPTRP00000007035 | ENSPTRP00000090739 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Neutral ceramidase. | 0.960 |
| ACER3 | CERK | ENSPTRP00000007035 | ENSPTRP00000087585 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Ceramide kinase. | 0.668 |
| ACER3 | DEGS1 | ENSPTRP00000007035 | ENSPTRP00000003391 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Degenerative spermatocyte homolog 1, lipid desaturase. | 0.941 |
| ACER3 | GALC | ENSPTRP00000007035 | ENSPTRP00000011226 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Galactosylceramidase. | 0.598 |
| ACER3 | SMPD1 | ENSPTRP00000007035 | ENSPTRP00000005756 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. | 0.598 |
| ACER3 | SPHK1 | ENSPTRP00000007035 | ENSPTRP00000052717 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine kinase 1. | 0.949 |
| ACER3 | SPHK2 | ENSPTRP00000007035 | ENSPTRP00000019290 | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | Sphingosine kinase 2. | 0.950 |
| ASAH1 | ACER1 | ENSPTRP00000063559 | ENSPTRP00000017621 | Acid ceramidase subunit alpha; Lysosomal ceramidase that hydrolyzes sphingolipid ceramides into sphingosine and free fatty acids at acidic pH (By similarity). Ceramides, sphingosine, and its phosphorylated form sphingosine-1- phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation (By similarity). Has a higher catalytic efficiency towards C12-ceramides versus other ceramides (By similarity). Also catalyzes the reverse reaction allowing the synthesis of ceramides from fatt [...] | Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. | 0.963 |
