| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFMID | DDC | ENSPTRP00000016506 | ENSPTRP00000091008 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Dopa decarboxylase. | 0.909 |
| AFMID | IDO1 | ENSPTRP00000016506 | ENSPTRP00000034569 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | IDO1 isoform 2. | 0.954 |
| AFMID | KYNU | ENSPTRP00000016506 | ENSPTRP00000067734 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.985 |
| AFMID | TDO2 | ENSPTRP00000016506 | ENSPTRP00000028403 | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.981 |
| CYP1A1 | CYP1B1 | ENSPTRP00000058539 | ENSPTRP00000020335 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | 0.944 |
| CYP1A1 | IDO1 | ENSPTRP00000058539 | ENSPTRP00000034569 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | IDO1 isoform 2. | 0.932 |
| CYP1A1 | TDO2 | ENSPTRP00000058539 | ENSPTRP00000028403 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.537 |
| CYP1A1 | TPH1 | ENSPTRP00000058539 | ENSPTRP00000078167 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Tryptophan hydroxylase 1. | 0.544 |
| CYP1A1 | TPH2 | ENSPTRP00000058539 | ENSPTRP00000088217 | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | Tryptophan hydroxylase 2. | 0.575 |
| CYP1B1 | CYP1A1 | ENSPTRP00000020335 | ENSPTRP00000058539 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Cytochrome P450 family 1 subfamily A member 1; Belongs to the cytochrome P450 family. | 0.944 |
| CYP1B1 | IDO1 | ENSPTRP00000020335 | ENSPTRP00000034569 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | IDO1 isoform 2. | 0.959 |
| CYP1B1 | TDO2 | ENSPTRP00000020335 | ENSPTRP00000028403 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.434 |
| CYP1B1 | TPH1 | ENSPTRP00000020335 | ENSPTRP00000078167 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Tryptophan hydroxylase 1. | 0.577 |
| CYP1B1 | TPH2 | ENSPTRP00000020335 | ENSPTRP00000088217 | Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. | Tryptophan hydroxylase 2. | 0.610 |
| DDC | AFMID | ENSPTRP00000091008 | ENSPTRP00000016506 | Dopa decarboxylase. | Kynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. | 0.909 |
| DDC | IDO1 | ENSPTRP00000091008 | ENSPTRP00000034569 | Dopa decarboxylase. | IDO1 isoform 2. | 0.963 |
| DDC | KYNU | ENSPTRP00000091008 | ENSPTRP00000067734 | Dopa decarboxylase. | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. | 0.564 |
| DDC | MAOA | ENSPTRP00000091008 | ENSPTRP00000037440 | Dopa decarboxylase. | Amine oxidase. | 0.973 |
| DDC | MAOB | ENSPTRP00000091008 | ENSPTRP00000037441 | Dopa decarboxylase. | Amine oxidase. | 0.976 |
| DDC | TDO2 | ENSPTRP00000091008 | ENSPTRP00000028403 | Dopa decarboxylase. | Tryptophan 2,3-dioxygenase; Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L- tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety. | 0.962 |
