STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SDC2Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)    
Predicted Functional Partners:
SDC4
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
  
 
0.995
GPC1
GPC1 isoform 1; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.
    
 0.978
SDC1
Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family.
  
 
0.973
EZR
EZR isoform 1.
    
 0.957
RDX
RDX isoform 3.
    
 0.912
MSN
MSN isoform 1.
    
 0.912
TGFB1
Transforming growth factor beta; Belongs to the TGF-beta family.
     
 0.910
CASK
Calcium/calmodulin dependent serine protein kinase; Belongs to the MAGUK family.
    
 0.858
TRAPPC4
Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.
     
 0.847
FGF2
Fibroblast growth factor 2; Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4. Also acts as an integrin ligand which is required for FGF2 signaling. Binds to integrin ITGAV:ITGB3. Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration. Functions as a potent mitogen in vitro. Can induce angiogenesis.
    
 0.749
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.