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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTK2Protein tyrosine kinase 2; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1113 aa)    
Predicted Functional Partners:
GRB2
Growth factor receptor-bound protein 2.
   
 0.999
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.998
SRC
Tyrosine-protein kinase.
   
0.996
EGFR
Receptor protein-tyrosine kinase.
    
0.995
BCAR1
BCAR1 scaffold protein, Cas family member.
    
 0.991
TLN1
TLN1 isoform 1.
    
 0.959
PXN
PXN isoform 20.
    
 0.956
PXN-2
PXN isoform 9.
    
 0.956
TLN2
TLN2 isoform 1.
    
 0.940
CRK
V-crk sarcoma virus CT10 oncogene homolog (Avian).
    
 0.938
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.