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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDKN2ACyclin-dependent kinase inhibitor 2A (Melanoma, p16, inhibits CDK4). (173 aa)    
Predicted Functional Partners:
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.718
CDKN2B
Cyclin-dependent kinase inhibitor 2B (P15, inhibits CDK4).
   
  
 0.676
MDM4
Protein Mdm4; Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Belongs to the MDM2/MDM4 family.
   
 0.592
MDM2
E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.
   
 0.592
CDK4
Cyclin-dependent kinase 4; Belongs to the protein kinase superfamily.
    
 0.536
CDK6
Cyclin-dependent kinase 6; Belongs to the protein kinase superfamily.
    
 0.535
KRAS
V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog.
   
 0.504
CCND1
CCND1 isoform 1; Belongs to the cyclin family.
    
 0.500
CDKN1B
Cyclin-dependent kinase inhibitor 1B (P27, Kip1).
    
 0.477
SMAD4
Mothers against decapentaplegic homolog.
    
 
 0.476
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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