PRKACG protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CREB1	PRKACA	ENSPTRP00000072951	ENSPTRP00000018062	cAMP responsive element binding protein 1.	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.925
CREB1	PRKACB	ENSPTRP00000072951	ENSPTRP00000042330	cAMP responsive element binding protein 1.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.984
CREB1	PRKACG	ENSPTRP00000072951	ENSPTRP00000035898	cAMP responsive element binding protein 1.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.987
PDE4A	PPP1R1B	ENSPTRP00000092904	ENSPTRP00000015498	Phosphodiesterase.	Protein phosphatase 1 regulatory inhibitor subunit 1B.	0.608
PDE4A	PRKACA	ENSPTRP00000092904	ENSPTRP00000018062	Phosphodiesterase.	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.818
PDE4A	PRKACB	ENSPTRP00000092904	ENSPTRP00000042330	Phosphodiesterase.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.980
PDE4A	PRKACG	ENSPTRP00000092904	ENSPTRP00000035898	Phosphodiesterase.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.980
PLN	PRKACA	ENSPTRP00000076374	ENSPTRP00000018062	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.813
PLN	PRKACB	ENSPTRP00000076374	ENSPTRP00000042330	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.980
PLN	PRKACG	ENSPTRP00000076374	ENSPTRP00000035898	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.980
PPP1R1B	PDE4A	ENSPTRP00000015498	ENSPTRP00000092904	Protein phosphatase 1 regulatory inhibitor subunit 1B.	Phosphodiesterase.	0.608
PPP1R1B	PRKACA	ENSPTRP00000015498	ENSPTRP00000018062	Protein phosphatase 1 regulatory inhibitor subunit 1B.	PRKACA isoform 7; Belongs to the protein kinase superfamily.	0.813
PPP1R1B	PRKACB	ENSPTRP00000015498	ENSPTRP00000042330	Protein phosphatase 1 regulatory inhibitor subunit 1B.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.980
PPP1R1B	PRKACG	ENSPTRP00000015498	ENSPTRP00000035898	Protein phosphatase 1 regulatory inhibitor subunit 1B.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.980
PRKACA	CREB1	ENSPTRP00000018062	ENSPTRP00000072951	PRKACA isoform 7; Belongs to the protein kinase superfamily.	cAMP responsive element binding protein 1.	0.925
PRKACA	PDE4A	ENSPTRP00000018062	ENSPTRP00000092904	PRKACA isoform 7; Belongs to the protein kinase superfamily.	Phosphodiesterase.	0.818
PRKACA	PLN	ENSPTRP00000018062	ENSPTRP00000076374	PRKACA isoform 7; Belongs to the protein kinase superfamily.	Cardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.	0.813
PRKACA	PPP1R1B	ENSPTRP00000018062	ENSPTRP00000015498	PRKACA isoform 7; Belongs to the protein kinase superfamily.	Protein phosphatase 1 regulatory inhibitor subunit 1B.	0.813
PRKACA	PRKACB	ENSPTRP00000018062	ENSPTRP00000042330	PRKACA isoform 7; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit beta; Belongs to the protein kinase superfamily.	0.999
PRKACA	PRKACG	ENSPTRP00000018062	ENSPTRP00000035898	PRKACA isoform 7; Belongs to the protein kinase superfamily.	Protein kinase cAMP-activated catalytic subunit gamma; Belongs to the protein kinase superfamily.	0.997