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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TLE4TLE family member 4, transcriptional corepressor. (805 aa)    
Predicted Functional Partners:
TLE1
Transducin-like enhancer of split 1.
  
 
0.897
RASEF
RAS and EF-hand domain containing.
    
 
 0.875
FRMD3
FERM domain containing 3.
      
 0.874
TLE3
TLE family member 3, transcriptional corepressor.
  
 
0.858
TLE5
AES isoform 1.
    
0.849
TCF7L2
Transcription factor 7 like 2.
    
 0.786
TLE2
Transducin-like enhancer of split 2.
  
 
 
0.758
TCF7
Transcription factor 7.
    
 0.758
PAX5
PAX5 isoform 1.
    
 
 0.754
SNRPN
Small nuclear ribonucleoprotein-associated protein N.
      
 0.753
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.