| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CREBBP | CTNNB1 | ENSPTRP00000074980 | ENSPTRP00000044466 | CREB binding protein. | Catenin (Cadherin-associated protein), beta 1, 88kDa. | 0.997 |
| CREBBP | EP300 | ENSPTRP00000074980 | ENSPTRP00000024841 | CREB binding protein. | E1A binding protein p300. | 0.999 |
| CREBBP | HDAC2 | ENSPTRP00000074980 | ENSPTRP00000049696 | CREB binding protein. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.843 |
| CREBBP | KLF2 | ENSPTRP00000074980 | ENSPTRP00000018167 | CREB binding protein. | Kruppel-like factor 2 (Lung). | 0.730 |
| CREBBP | KLF4 | ENSPTRP00000074980 | ENSPTRP00000036269 | CREB binding protein. | Kruppel-like factor 4 (Gut). | 0.836 |
| CREBBP | MYC | ENSPTRP00000074980 | ENSPTRP00000075568 | CREB binding protein. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.795 |
| CREBBP | TP53 | ENSPTRP00000074980 | ENSPTRP00000014836 | CREB binding protein. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.997 |
| CTNNB1 | CREBBP | ENSPTRP00000044466 | ENSPTRP00000074980 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | CREB binding protein. | 0.997 |
| CTNNB1 | EP300 | ENSPTRP00000044466 | ENSPTRP00000024841 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | E1A binding protein p300. | 0.996 |
| CTNNB1 | HDAC2 | ENSPTRP00000044466 | ENSPTRP00000049696 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.823 |
| CTNNB1 | KLF2 | ENSPTRP00000044466 | ENSPTRP00000018167 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Kruppel-like factor 2 (Lung). | 0.630 |
| CTNNB1 | KLF4 | ENSPTRP00000044466 | ENSPTRP00000036269 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Kruppel-like factor 4 (Gut). | 0.782 |
| CTNNB1 | MYC | ENSPTRP00000044466 | ENSPTRP00000075568 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis. Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells. Functions with TAF6L to activate target gene expression through RNA polymerase II pause release (By similarity). | 0.949 |
| CTNNB1 | NANOG | ENSPTRP00000044466 | ENSPTRP00000007892 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Homeobox protein NANOG; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT] [...] | 0.750 |
| CTNNB1 | POU5F1 | ENSPTRP00000044466 | ENSPTRP00000030631 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | POU domain, class 5, transcription factor 1; Transcription factor that binds to the octamer motif (5'- ATTTGCAT-3'). Forms a trimeric complex with SOX2 or SOX15 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency (By similarity). | 0.757 |
| CTNNB1 | SOX2 | ENSPTRP00000044466 | ENSPTRP00000046752 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | SRY-box transcription factor 2. | 0.897 |
| CTNNB1 | TP53 | ENSPTRP00000044466 | ENSPTRP00000014836 | Catenin (Cadherin-associated protein), beta 1, 88kDa. | Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. | 0.724 |
| EP300 | CREBBP | ENSPTRP00000024841 | ENSPTRP00000074980 | E1A binding protein p300. | CREB binding protein. | 0.999 |
| EP300 | CTNNB1 | ENSPTRP00000024841 | ENSPTRP00000044466 | E1A binding protein p300. | Catenin (Cadherin-associated protein), beta 1, 88kDa. | 0.996 |
| EP300 | HDAC2 | ENSPTRP00000024841 | ENSPTRP00000049696 | E1A binding protein p300. | Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. | 0.866 |
