TLR4 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

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textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPTRP00000072328	LY96	ENSPTRP00000072328	ENSPTRP00000083213	annotation not available	Lymphocyte antigen 96.	0.675
ENSPTRP00000072328	TLR2	ENSPTRP00000072328	ENSPTRP00000028379	annotation not available	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.935
ENSPTRP00000072328	TLR4	ENSPTRP00000072328	ENSPTRP00000036398	annotation not available	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.978
HMGB1	LY96	ENSPTRP00000074016	ENSPTRP00000083213	HMGB1 isoform 1.	Lymphocyte antigen 96.	0.675
HMGB1	TLR2	ENSPTRP00000074016	ENSPTRP00000028379	HMGB1 isoform 1.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.950
HMGB1	TLR4	ENSPTRP00000074016	ENSPTRP00000036398	HMGB1 isoform 1.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.985
IRAK4	LY96	ENSPTRP00000008285	ENSPTRP00000083213	Interleukin-1 receptor-associated kinase 4.	Lymphocyte antigen 96.	0.493
IRAK4	MYD88	ENSPTRP00000008285	ENSPTRP00000061524	Interleukin-1 receptor-associated kinase 4.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...]	0.999
IRAK4	TICAM1	ENSPTRP00000008285	ENSPTRP00000049092	Interleukin-1 receptor-associated kinase 4.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.936
IRAK4	TICAM2	ENSPTRP00000008285	ENSPTRP00000063813	Interleukin-1 receptor-associated kinase 4.	TIR domain-containing adapter molecule 2.	0.433
IRAK4	TIRAP	ENSPTRP00000008285	ENSPTRP00000063957	Interleukin-1 receptor-associated kinase 4.	Toll-interleukin 1 receptor (TIR) domain containing adaptor protein.	0.989
IRAK4	TLR2	ENSPTRP00000008285	ENSPTRP00000028379	Interleukin-1 receptor-associated kinase 4.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.725
IRAK4	TLR4	ENSPTRP00000008285	ENSPTRP00000036398	Interleukin-1 receptor-associated kinase 4.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.988
LOC107970066	LY96	ENSPTRP00000063377	ENSPTRP00000083213	LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1.	Lymphocyte antigen 96.	0.675
LOC107970066	TLR2	ENSPTRP00000063377	ENSPTRP00000028379	LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.935
LOC107970066	TLR4	ENSPTRP00000063377	ENSPTRP00000036398	LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.982
LY96	ENSPTRP00000072328	ENSPTRP00000083213	ENSPTRP00000072328	Lymphocyte antigen 96.	annotation not available	0.675
LY96	HMGB1	ENSPTRP00000083213	ENSPTRP00000074016	Lymphocyte antigen 96.	HMGB1 isoform 1.	0.675
LY96	IRAK4	ENSPTRP00000083213	ENSPTRP00000008285	Lymphocyte antigen 96.	Interleukin-1 receptor-associated kinase 4.	0.493
LY96	LOC107970066	ENSPTRP00000083213	ENSPTRP00000063377	Lymphocyte antigen 96.	LOW QUALITY PROTEIN: putative high mobility group protein B1-like 1.	0.675