| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| C3 | C3AR1 | ENSPTRP00000017648 | ENSPTRP00000007901 | Complement component 3. | Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.971 |
| C3 | C5 | ENSPTRP00000017648 | ENSPTRP00000036418 | Complement component 3. | Complement C5. | 0.973 |
| C3 | C5AR1 | ENSPTRP00000017648 | ENSPTRP00000054387 | Complement component 3. | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. | 0.633 |
| C3 | C5AR2 | ENSPTRP00000017648 | ENSPTRP00000060888 | Complement component 3. | Complement component 5a receptor 2. | 0.808 |
| C3 | C6 | ENSPTRP00000017648 | ENSPTRP00000028843 | Complement component 3. | Complement component C6; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Belongs to the complement C6/C7/C8/C9 family. | 0.602 |
| C3 | C7 | ENSPTRP00000017648 | ENSPTRP00000039456 | Complement component 3. | Complement component 7. | 0.555 |
| C3 | C9 | ENSPTRP00000017648 | ENSPTRP00000028833 | Complement component 3. | Complement C9. | 0.658 |
| C3 | F2 | ENSPTRP00000017648 | ENSPTRP00000006168 | Complement component 3. | Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. | 0.477 |
| C3AR1 | C3 | ENSPTRP00000007901 | ENSPTRP00000017648 | Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. | Complement component 3. | 0.971 |
| C3AR1 | C5 | ENSPTRP00000007901 | ENSPTRP00000036418 | Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. | Complement C5. | 0.968 |
| C3AR1 | C5AR1 | ENSPTRP00000007901 | ENSPTRP00000054387 | Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. | 0.408 |
| C3AR1 | C5AR2 | ENSPTRP00000007901 | ENSPTRP00000060888 | Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. | Complement component 5a receptor 2. | 0.408 |
| C5 | C3 | ENSPTRP00000036418 | ENSPTRP00000017648 | Complement C5. | Complement component 3. | 0.973 |
| C5 | C3AR1 | ENSPTRP00000036418 | ENSPTRP00000007901 | Complement C5. | Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. | 0.968 |
| C5 | C5AR1 | ENSPTRP00000036418 | ENSPTRP00000054387 | Complement C5. | C5a anaphylatoxin chemotactic receptor 1; Receptor for the chemotactic and inflammatory peptide anaphylatoxin C5a. The ligand interacts with at least two sites on the receptor: a high-affinity site on the extracellular N-terminus, and a second site in the transmembrane region which activates downstream signaling events. Receptor activation stimulates chemotaxis, granule enzyme release, intracellular calcium release and superoxide anion production. | 0.994 |
| C5 | C5AR2 | ENSPTRP00000036418 | ENSPTRP00000060888 | Complement C5. | Complement component 5a receptor 2. | 0.959 |
| C5 | C6 | ENSPTRP00000036418 | ENSPTRP00000028843 | Complement C5. | Complement component C6; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells; Belongs to the complement C6/C7/C8/C9 family. | 0.999 |
| C5 | C7 | ENSPTRP00000036418 | ENSPTRP00000039456 | Complement C5. | Complement component 7. | 0.998 |
| C5 | C8B | ENSPTRP00000036418 | ENSPTRP00000093451 | Complement C5. | C8B isoform 5. | 0.936 |
| C5 | C8G | ENSPTRP00000036418 | ENSPTRP00000036958 | Complement C5. | Complement C8 gamma chain; Belongs to the calycin superfamily. Lipocalin family. | 0.932 |
