| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| DHFR | DHFR2 | ENSPTRP00000029175 | ENSPTRP00000091206 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | DHFR2 isoform 2. | 0.972 |
| DHFR | ENSPTRP00000082302 | ENSPTRP00000029175 | ENSPTRP00000082302 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | annotation not available | 0.504 |
| DHFR | ENSPTRP00000092611 | ENSPTRP00000029175 | ENSPTRP00000092611 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | annotation not available | 0.739 |
| DHFR | FPGS | ENSPTRP00000029175 | ENSPTRP00000085569 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.979 |
| DHFR | GGH | ENSPTRP00000029175 | ENSPTRP00000034736 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Folate gamma-glutamyl hydrolase. | 0.930 |
| DHFR | MTHFD1 | ENSPTRP00000029175 | ENSPTRP00000010916 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | MTHFD1 isoform 1. | 0.963 |
| DHFR | MTHFD1L | ENSPTRP00000029175 | ENSPTRP00000031922 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. | 0.956 |
| DHFR | SHMT1 | ENSPTRP00000029175 | ENSPTRP00000076664 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase 1. | 0.976 |
| DHFR | SHMT2 | ENSPTRP00000029175 | ENSPTRP00000063004 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.978 |
| DHFR | TYMS | ENSPTRP00000029175 | ENSPTRP00000016716 | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | Thymidylate synthetase. | 0.999 |
| DHFR2 | DHFR | ENSPTRP00000091206 | ENSPTRP00000029175 | DHFR2 isoform 2. | Dihydrofolate reductase; Belongs to the dihydrofolate reductase family. | 0.972 |
| DHFR2 | ENSPTRP00000082302 | ENSPTRP00000091206 | ENSPTRP00000082302 | DHFR2 isoform 2. | annotation not available | 0.504 |
| DHFR2 | ENSPTRP00000092611 | ENSPTRP00000091206 | ENSPTRP00000092611 | DHFR2 isoform 2. | annotation not available | 0.739 |
| DHFR2 | FPGS | ENSPTRP00000091206 | ENSPTRP00000085569 | DHFR2 isoform 2. | Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. | 0.977 |
| DHFR2 | GGH | ENSPTRP00000091206 | ENSPTRP00000034736 | DHFR2 isoform 2. | Folate gamma-glutamyl hydrolase. | 0.925 |
| DHFR2 | MTHFD1 | ENSPTRP00000091206 | ENSPTRP00000010916 | DHFR2 isoform 2. | MTHFD1 isoform 1. | 0.957 |
| DHFR2 | MTHFD1L | ENSPTRP00000091206 | ENSPTRP00000031922 | DHFR2 isoform 2. | Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like. | 0.958 |
| DHFR2 | SHMT1 | ENSPTRP00000091206 | ENSPTRP00000076664 | DHFR2 isoform 2. | Serine hydroxymethyltransferase 1. | 0.972 |
| DHFR2 | SHMT2 | ENSPTRP00000091206 | ENSPTRP00000063004 | DHFR2 isoform 2. | Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. | 0.972 |
| DHFR2 | TYMS | ENSPTRP00000091206 | ENSPTRP00000016716 | DHFR2 isoform 2. | Thymidylate synthetase. | 0.999 |
