ABL1 protein (Pan troglodytes) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Pan troglodytes

NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc.

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABI1	ABL1	ENSPTRP00000045168	ENSPTRP00000072918	Abl interactor 1.	Tyrosine-protein kinase.	0.925
ABI1	CBL	ENSPTRP00000045168	ENSPTRP00000007497	Abl interactor 1.	Cas-Br-M (Murine) ecotropic retroviral transforming sequence.	0.672
ABI1	CRK	ENSPTRP00000045168	ENSPTRP00000083173	Abl interactor 1.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.706
ABI1	GRB2	ENSPTRP00000045168	ENSPTRP00000016382	Abl interactor 1.	Growth factor receptor-bound protein 2.	0.657
ABI1	PIK3R1	ENSPTRP00000045168	ENSPTRP00000076964	Abl interactor 1.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.475
ABL1	ABI1	ENSPTRP00000072918	ENSPTRP00000045168	Tyrosine-protein kinase.	Abl interactor 1.	0.925
ABL1	ATM	ENSPTRP00000072918	ENSPTRP00000054216	Tyrosine-protein kinase.	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	0.941
ABL1	BCR	ENSPTRP00000072918	ENSPTRP00000039219	Tyrosine-protein kinase.	BCR activator of RhoGEF and GTPase.	0.914
ABL1	CBL	ENSPTRP00000072918	ENSPTRP00000007497	Tyrosine-protein kinase.	Cas-Br-M (Murine) ecotropic retroviral transforming sequence.	0.858
ABL1	CRK	ENSPTRP00000072918	ENSPTRP00000083173	Tyrosine-protein kinase.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.840
ABL1	DOK1	ENSPTRP00000072918	ENSPTRP00000020765	Tyrosine-protein kinase.	Docking protein 1, 62kDa (Downstream of tyrosine kinase 1).	0.855
ABL1	GRB2	ENSPTRP00000072918	ENSPTRP00000016382	Tyrosine-protein kinase.	Growth factor receptor-bound protein 2.	0.810
ABL1	HSP90AA1	ENSPTRP00000072918	ENSPTRP00000070946	Tyrosine-protein kinase.	Heat shock protein HSP 90-alpha; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity which is essential for its chaperone activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a ra [...]	0.812
ABL1	PIK3R1	ENSPTRP00000072918	ENSPTRP00000076964	Tyrosine-protein kinase.	Phosphoinositide-3-kinase, regulatory subunit 1 (Alpha).	0.833
ABL1	RIN1	ENSPTRP00000072918	ENSPTRP00000047896	Tyrosine-protein kinase.	Ras and Rab interactor 1.	0.830
ATM	ABL1	ENSPTRP00000054216	ENSPTRP00000072918	Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...]	Tyrosine-protein kinase.	0.941
BCR	ABL1	ENSPTRP00000039219	ENSPTRP00000072918	BCR activator of RhoGEF and GTPase.	Tyrosine-protein kinase.	0.914
BCR	CBL	ENSPTRP00000039219	ENSPTRP00000007497	BCR activator of RhoGEF and GTPase.	Cas-Br-M (Murine) ecotropic retroviral transforming sequence.	0.983
BCR	CRK	ENSPTRP00000039219	ENSPTRP00000083173	BCR activator of RhoGEF and GTPase.	V-crk sarcoma virus CT10 oncogene homolog (Avian).	0.940
BCR	GRB2	ENSPTRP00000039219	ENSPTRP00000016382	BCR activator of RhoGEF and GTPase.	Growth factor receptor-bound protein 2.	0.995