node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGEF5 | ARHGEF6 | ENSPTRP00000033951 | ENSPTRP00000043151 | ARHGEF5 isoform 2. | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. | 0.768 |
ARHGEF5 | ASPM | ENSPTRP00000033951 | ENSPTRP00000051373 | ARHGEF5 isoform 2. | Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). | 0.579 |
ARHGEF5 | GM2A | ENSPTRP00000033951 | ENSPTRP00000085826 | ARHGEF5 isoform 2. | GM2 ganglioside activator. | 0.475 |
ARHGEF5 | OPHN1 | ENSPTRP00000033951 | ENSPTRP00000088982 | ARHGEF5 isoform 2. | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). | 0.727 |
ARHGEF5 | OSBPL8 | ENSPTRP00000033951 | ENSPTRP00000008904 | ARHGEF5 isoform 2. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.464 |
ARHGEF6 | ARHGEF5 | ENSPTRP00000043151 | ENSPTRP00000033951 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. | ARHGEF5 isoform 2. | 0.768 |
ARHGEF6 | ASPM | ENSPTRP00000043151 | ENSPTRP00000051373 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. | Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). | 0.621 |
ARHGEF6 | GM2A | ENSPTRP00000043151 | ENSPTRP00000085826 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. | GM2 ganglioside activator. | 0.627 |
ARHGEF6 | OPHN1 | ENSPTRP00000043151 | ENSPTRP00000088982 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). | 0.747 |
ARHGEF6 | OSBPL8 | ENSPTRP00000043151 | ENSPTRP00000008904 | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.638 |
ASPM | ARHGEF5 | ENSPTRP00000051373 | ENSPTRP00000033951 | Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). | ARHGEF5 isoform 2. | 0.579 |
ASPM | ARHGEF6 | ENSPTRP00000051373 | ENSPTRP00000043151 | Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. | 0.621 |
ASPM | OPHN1 | ENSPTRP00000051373 | ENSPTRP00000088982 | Abnormal spindle-like microcephaly-associated protein homolog; Probable role in mitotic spindle regulation and coordination of mitotic processes. May have a preferential role in regulating neurogenesis (By similarity). | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). | 0.600 |
FANCC | OPHN1 | ENSPTRP00000036132 | ENSPTRP00000088982 | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). | 0.650 |
GM2A | ARHGEF5 | ENSPTRP00000085826 | ENSPTRP00000033951 | GM2 ganglioside activator. | ARHGEF5 isoform 2. | 0.475 |
GM2A | ARHGEF6 | ENSPTRP00000085826 | ENSPTRP00000043151 | GM2 ganglioside activator. | Rac/Cdc42 guanine nucleotide exchange factor (GEF) 6. | 0.627 |
GM2A | OPHN1 | ENSPTRP00000085826 | ENSPTRP00000088982 | GM2 ganglioside activator. | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). | 0.585 |
GM2A | OSBPL8 | ENSPTRP00000085826 | ENSPTRP00000008904 | GM2 ganglioside activator. | Oxysterol-binding protein; Belongs to the OSBP family. | 0.891 |
HOMER1 | OPHN1 | ENSPTRP00000084197 | ENSPTRP00000088982 | HOMER1 isoform 1. | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). | 0.578 |
OPCML | OPHN1 | ENSPTRP00000007679 | ENSPTRP00000088982 | Opioid-binding protein/cell adhesion molecule; Binds opioids in the presence of acidic lipids; probably involved in cell contact; Belongs to the immunoglobulin superfamily. IgLON family. | Oligophrenin-1; Stimulates GTP hydrolysis of members of the Rho family. Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function. Critical for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at pre- synaptic terminals. Required for the localization of NR1D1 to dendrites, can suppress its repressor activity and protect it from proteasomal degradation (By similarity). | 0.604 |