STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (853 aa)    
Predicted Functional Partners:
DLG1
Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.
  
 
0.993
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
  
 
0.985
DLG2
Discs large MAGUK scaffold protein 2.
  
 
0.985
GRIN2B
Glutamate ionotropic receptor NMDA type subunit 2B.
    
 0.977
GRIN2A
Glutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...]
    
 0.967
NBEA
NBEA isoform 7.
   
 0.941
NEDD4
NEDD4 E3 ubiquitin protein ligase.
   
 0.939
TJAP1
Tight junction associated protein 1.
   
 0.929
NEDD4L
NEDD4L isoform 6.
   
 0.915
UBE3A
Ubiquitin-protein ligase E3A; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.
    
 0.908
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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