Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
DLG3Discs large MAGUK scaffold protein 3; Belongs to the MAGUK family. (853 aa)    
Predicted Functional Partners:
DLG1
Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family.
  
0.996
DLG2
Discs large MAGUK scaffold protein 2.
  
0.995
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
  
0.992
GRIN2B
Glutamate ionotropic receptor NMDA type subunit 2B.
   
 0.983
GRIN2A
Glutamate receptor ionotropic, NMDA 2A; Component of NMDA receptor complexes that function as heterotetrameric, ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Channel activation requires binding of the neurotransmitter glutamate to the epsilon subunit, glycine binding to the zeta subunit, plus membrane depolarization to eliminate channel inhibition by Mg(2+). Sensitivity to glutamate and channel kinetics depend on the subunit composition; channels containing GRIN1 and GRIN2A have higher sensitivity to glutamate and faster kineti [...]
   
 0.964
TJAP1
Tight junction associated protein 1.
   
 0.942
NEDD4L
NEDD4L isoform 6.
    
 0.930
NEDD4
NEDD4 E3 ubiquitin protein ligase.
    
 0.929
GRIN1
Glutamate receptor, ionotropic, N-methyl D-aspartate 1.
   
 0.922
SCRIB-2
Scribbled homolog.
   
0.920
Your Current Organism:
Pan troglodytes
NCBI taxonomy Id: 9598
Other names: P. troglodytes, chimpanzee
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