| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| IL1R1 | IRAK1-2 | ENSPTRP00000075043 | ENSPTRP00000038647 | Interleukin 1 receptor, type I. | Interleukin-1 receptor-associated kinase 1. | 0.992 |
| IL1R1 | IRAK2 | ENSPTRP00000075043 | ENSPTRP00000025212 | Interleukin 1 receptor, type I. | Interleukin-1 receptor-associated kinase 2. | 0.881 |
| IL1R1 | IRAK4 | ENSPTRP00000075043 | ENSPTRP00000008285 | Interleukin 1 receptor, type I. | Interleukin-1 receptor-associated kinase 4. | 0.991 |
| IL1R1 | MYD88 | ENSPTRP00000075043 | ENSPTRP00000061524 | Interleukin 1 receptor, type I. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.998 |
| IL1R1 | TIRAP | ENSPTRP00000075043 | ENSPTRP00000063957 | Interleukin 1 receptor, type I. | Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. | 0.621 |
| IL1R1 | TRAF6 | ENSPTRP00000075043 | ENSPTRP00000006096 | Interleukin 1 receptor, type I. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.995 |
| IRAK1-2 | IL1R1 | ENSPTRP00000038647 | ENSPTRP00000075043 | Interleukin-1 receptor-associated kinase 1. | Interleukin 1 receptor, type I. | 0.992 |
| IRAK1-2 | IRAK2 | ENSPTRP00000038647 | ENSPTRP00000025212 | Interleukin-1 receptor-associated kinase 1. | Interleukin-1 receptor-associated kinase 2. | 0.986 |
| IRAK1-2 | IRAK4 | ENSPTRP00000038647 | ENSPTRP00000008285 | Interleukin-1 receptor-associated kinase 1. | Interleukin-1 receptor-associated kinase 4. | 0.997 |
| IRAK1-2 | IRF7 | ENSPTRP00000038647 | ENSPTRP00000073107 | Interleukin-1 receptor-associated kinase 1. | Interferon regulatory factor 7. | 0.983 |
| IRAK1-2 | MAP3K7 | ENSPTRP00000038647 | ENSPTRP00000057993 | Interleukin-1 receptor-associated kinase 1. | Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. | 0.987 |
| IRAK1-2 | MYD88 | ENSPTRP00000038647 | ENSPTRP00000061524 | Interleukin-1 receptor-associated kinase 1. | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Increases IL-8 transcription. Involved in IL-18-mediated signaling pathway. Activates IRF1 resulting in its rapid migration into the nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS, and IL12A genes (By similarity). MyD88-mediated signaling in intestinal epithelial cells is cruc [...] | 0.997 |
| IRAK1-2 | TAB2 | ENSPTRP00000038647 | ENSPTRP00000031895 | Interleukin-1 receptor-associated kinase 1. | TGF-beta activated kinase 1 (MAP3K7) binding protein 2. | 0.992 |
| IRAK1-2 | TAB3 | ENSPTRP00000038647 | ENSPTRP00000047463 | Interleukin-1 receptor-associated kinase 1. | TGF-beta activated kinase 1 (MAP3K7) binding protein 3. | 0.976 |
| IRAK1-2 | TIRAP | ENSPTRP00000038647 | ENSPTRP00000063957 | Interleukin-1 receptor-associated kinase 1. | Toll-interleukin 1 receptor (TIR) domain containing adaptor protein. | 0.974 |
| IRAK1-2 | TRAF6 | ENSPTRP00000038647 | ENSPTRP00000006096 | Interleukin-1 receptor-associated kinase 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.998 |
| IRAK2 | IL1R1 | ENSPTRP00000025212 | ENSPTRP00000075043 | Interleukin-1 receptor-associated kinase 2. | Interleukin 1 receptor, type I. | 0.881 |
| IRAK2 | IRAK1-2 | ENSPTRP00000025212 | ENSPTRP00000038647 | Interleukin-1 receptor-associated kinase 2. | Interleukin-1 receptor-associated kinase 1. | 0.986 |
| IRAK2 | IRAK4 | ENSPTRP00000025212 | ENSPTRP00000008285 | Interleukin-1 receptor-associated kinase 2. | Interleukin-1 receptor-associated kinase 4. | 0.995 |
| IRAK2 | IRF7 | ENSPTRP00000025212 | ENSPTRP00000073107 | Interleukin-1 receptor-associated kinase 2. | Interferon regulatory factor 7. | 0.643 |
